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Home / Primary Antibodies / Polyclonal Antibodies

Anti-AFG3L2 Antibody Picoband®

SKU : BHA21000816

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Mfr.No.	PB9915, PB9915-10ug, PB9915-Biotin, PB9915-Cy3, PB9915-Dylight488, PB9915-Dylight550, PB9915-Dylight594, PB9915-FITC, PB9915-HRP, PB9915-APC, PB9915-PE, PB9915-iFluor647, PB9915-carrier-free
Alternative Names	AFG3-like protein 2
Background	AFG3L2 is the catalytic subunit of the m-AAA protease, an ATP-dependent proteolytic complex of the mitochondrial inner membrane that degrades misfolded proteins and regulates ribosome assembly. In humans, it is encoded by the AFG3L2 gene. This gene encodes a protein localized in mitochondria and closely related to paraplegin. The paraplegin gene is responsible for an autosomal recessive form of hereditary spastic paraplegia. And this gene is a candidate gene for other hereditary spastic paraplegias or neurodegenerative disorders as well as spastic ataxia-neuropathy syndrome.
Clonality	Polyclonal
Cross Reactivity	No cross-reactivity with other proteins
Description	Boster Bio Anti-AFG3L2 Antibody Picoband® catalog # PB9915. Tested in Flow Cytometry, IF, ICC, WB applications. This antibody reacts with Human, Mouse, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Weste blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.
Function	ATP-dependent protease which is essential for axonal development. .
Host	Rabbit
Immunogen Region	E. coli-derived human AFG3L2 recombinant protein (Position: R168-D250). Human AFG3L2 shares 100% amino acid (aa) sequence identity with mouse AFG3L2.
Isotype	Rabbit IgG
Molecular Weight	89 kDa
Reactivity	Human, Mouse, Rat
Reconstitution	Add 0.2ml of distilled water will yield a concentration of 500ug/ml.
Specificity	No cross reactivity with other proteins.
Synonyms	AFG3-like protein 2;3.4.24.-;Paraplegin-like protein;AFG3L2;
Tissue Specificity	Ubiquitous. Highly expressed in the cerebellar Purkinje cells. .
Note	Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg NaN3.

Uniprot	Q9Y4W6
Gene Id	10939
Gene Name	AFG3L2
Subcellular Location	Mitochondrion membrane ; Multi-pass membrane protein .

Conjugates	Biotin, Cy3, Dylight488, Dylight550, Dylight594, FITC, HRP, APC, PE, iFluor647, carrier-free

Concentration	Adding 0.2 ml of distilled water will yield a concentration of 500 ug/ml.
Form	Lyophilized
Purification	Immunogen affinity purified.
Storage	Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

Applications	Flow Cytometry, IF, ICC, WB
Description	Weste blot, 0.1-0.5ug/ml, Human, Mouse, Rat Immunocytochemistry/Immunofluorescence, 2ug/ml, Human Flow Cytometry (Fixed), 1-3ug/1x10⁶ cells, Human

Reference	1. "Entrez Gene: AFG3 ATPase family gene 3-like 2 (S. cerevisiae)". 2. Koppen, M., Metodiev, M. D., Casari, G., Rugarli, E. I., Langer, T. Variable and tissue-specific subunit composition of mitochondrial m-AAA protease complexes linked to hereditary spastic paraplegia. Molec. Cell. Biol. 27: 758-767, 2007. 3. Pierson TM, Adams D, Bonn F, Martinelli P, Cherukuri PF, Teer JK, Hansen NF, Cruz P, Mullikin For The Nisc Comparative Sequencing Program JC, Blakesley RW, Golas G, Kwan J, Sandler A, Fuentes Fajardo K, Markello T, Tifft C, Blackstone C, Rugarli EI, Langer T, Gahl WA, Toro C (October 2011). "Whole-exome sequencing identifies homozygous AFG3L2 mutations in a spastic ataxia-neuropathy syndrome linked to mitochondrial m-AAA proteases". PLoS Genet. 7 (10): e1002325.

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Combination SKU	Supplier No.	Size	Conjugation	Your price	Quantity
BHA21000816-1	PB9915	100 ug	-	$370		Add to Cart
BHA21000816-2	PB9915-10ug	10 ug	Sample	$99		Add to Cart
BHA21000816-3	PB9915-Biotin	100 ug	Biotin	$570		Add to Cart
BHA21000816-4	PB9915-Cy3	100 ug	Cy3	$570		Add to Cart
BHA21000816-5	PB9915-Dylight488	100 ug	Dylight488	$570		Add to Cart
BHA21000816-6	PB9915-Dylight550	100 ug	Dylight550	$570		Add to Cart
BHA21000816-7	PB9915-Dylight594	100 ug	Dylight594	$570		Add to Cart
BHA21000816-8	PB9915-FITC	100 ug	FITC	$570		Add to Cart
BHA21000816-9	PB9915-HRP	100 ug	HRP	$570		Add to Cart
BHA21000816-10	PB9915-APC	100 ug	APC	$670		Add to Cart
BHA21000816-11	PB9915-PE	100 ug	PE	$670		Add to Cart
BHA21000816-12	PB9915-iFluor647	100 ug	iFluor647	$670		Add to Cart
BHA21000816-13	PB9915-carrier-free	100 ug	carrier-free	$370		Add to Cart

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