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Home / Primary Antibodies / Polyclonal Antibodies

Anti-ADRM1/ARM-1 Antibody Picoband®

SKU : BHA21003516

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Mfr.No.	A04010-2, A04010-2-10ug, A04010-2-Biotin, A04010-2-Cy3, A04010-2-Dylight488, A04010-2-Dylight550, A04010-2-Dylight594, A04010-2-FITC, A04010-2-HRP, A04010-2-APC, A04010-2-PE, A04010-2-iFluor647, A04010-2-carrier-free
Alternative Names	Ran-specific GTPase-activating protein
Background	Proteasomal ubiquitin receptor ADRM1 is a protein that in humans is encoded by the ADRM1 gene. This gene encodes a member of the adhesion regulating molecule 1 protein family. The encoded protein is a component of the proteasome where it acts as a ubiquitin receptor and recruits the deubiquitinating enzyme, ubiquitin carboxyl-terminal hydrolase L5. Increased levels of the encoded protein are associated with increased cell adhesion, which is likely an in effect of this intracellular protein. Dysregulation of this gene has been implicated in carcinogenesis. Alteative splicing results in multiple transcript variants.
Clonality	Polyclonal
Cross Reactivity	No cross-reactivity with other proteins.
Description	Boster Bio Anti-ADRM1/ARM-1 Antibody Picoband® catalog # A04010-2. Tested in ELISA, Flow Cytometry, IF, IHC, ICC, WB applications. This antibody reacts with Human, Mouse, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Weste blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.
Function	Inhibits GTP exchange on Ran. Forms a Ran-GTP-RANBP1 trimeric complex. Increase GTP hydrolysis induced by the Ran GTPase activating protein RANGAP1. May act in an intracellular signaling pathway which may control the progression through the cell cycle by
Host	Rabbit
Immunogen Region	E.coli-derived human ADRM1/ARM-1 recombinant protein (Position: S15-K390).
Isotype	Rabbit IgG
Molecular Weight	42 kDa
Reactivity	Human, Mouse, Rat
Reconstitution	Adding 0.2 ml of distilled water will yield a concentration of 500 ug/ml.
Synonyms	Ran-specific GTPase-activating protein;Ran-binding protein 1;RanBP1;RANBP1;
Tissue Specificity	Ubiquitously expressed. Present at highest levels in the brain, at high levels in the placenta and testis, at intermediate levels in the intestine, ovary, skeletal muscle and thymus and at lower levels in heart, kidney, liver, lung, pancreas, prostate and spleen. In the kidney, it is widely expressed in tubules, but sparsely expressed in the glomerulus (PubMed:24676636). Expression is significantly increased in renal biopsy specimens from idiopathic FSGS (PubMed:24676636). Overexpressed in many tumor types including breast, colorectal, endometrial, hepatic, kidney, lung, ovarian and pancreatic tumors.
Note	Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.

Uniprot	Q16186
Gene Id	11047
Gene Name	ADRM1
Subcellular Location	Cytoskeleton. Nucleus. Cell cortex. Bleb.

Conjugates	Biotin, Cy3, Dylight488, Dylight550, Dylight594, FITC, HRP, APC, PE, iFluor647, carrier-free

Concentration	Adding 0.2 ml of distilled water will yield a concentration of 500 ug/ml.
Form	Lyophilized
Purification	Immunogen affinity purified.
Storage	At -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freezing and thawing.

Applications	WB, IHC, ICC, IF, Flow Cytometry, ELISA
Description	Weste blot, 0.25-0.5 ug/ml, Human, Mouse, Rat Immunohistochemistry(Paraffin-embedded Section), 2-5 ug/ml, Human, Mouse, Rat Immunocytochemistry/Immunofluorescence, 5 ug/ml, Human Flow Cytometry (Fixed), 1-3 ug/1x10⁶ cells, Human ELISA, 0.1-0.5 ug/ml, -

Reference	1. Husnjak, K., Elsasser, S., Zhang, N., Chen, X., Randles, L., Shi, Y., Hofmann, K., Walters, K. J., Finley, D., Dikic, I. Proteasome subunit Rpn13 is a novel ubiquitin receptor. Nature 453: 481-488, 2008. 2. Jorgensen, J. P., Lauridsen, A.-M., Kristensen, P., Dissing, K., Johnsen, A. H., Hendil, K. B., Hartmann-Petersen, R. Adrm1, a putative cell adhesion regulating protein, is a novel proteasome-associated factor. J. Molec. Biol. 360: 1043-1052, 2006. 3. Lamerant, N., Kieda, C. Adhesion properties of adhesion-regulating molecule 1 protein on endothelial cells. FEBS J. 272: 1833-1844, 2005.

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Combination SKU	Supplier No.	Conjugation	Size	Your price	Quantity
BHA21003516-1	A04010-2	-	100 ug	$370		Add to Cart
BHA21003516-2	A04010-2-10ug	Sample	10 ug	$99		Add to Cart
BHA21003516-3	A04010-2-Biotin	Biotin	100 ug	$570		Add to Cart
BHA21003516-4	A04010-2-Cy3	Cy3	100 ug	$570		Add to Cart
BHA21003516-5	A04010-2-Dylight488	Dylight488	100 ug	$570		Add to Cart
BHA21003516-6	A04010-2-Dylight550	Dylight550	100 ug	$570		Add to Cart
BHA21003516-7	A04010-2-Dylight594	Dylight594	100 ug	$570		Add to Cart
BHA21003516-8	A04010-2-FITC	FITC	100 ug	$570		Add to Cart
BHA21003516-9	A04010-2-HRP	HRP	100 ug	$570		Add to Cart
BHA21003516-10	A04010-2-APC	APC	100 ug	$670		Add to Cart
BHA21003516-11	A04010-2-PE	PE	100 ug	$670		Add to Cart
BHA21003516-12	A04010-2-iFluor647	iFluor647	100 ug	$670		Add to Cart
BHA21003516-13	A04010-2-carrier-free	carrier-free	100 ug	$370		Add to Cart

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