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Home / Primary Antibodies / Polyclonal Antibodies

Anti-ADAM15 Antibody Picoband®

SKU : BHA21002492

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Mfr.No.	A02593-4, A02593-4-10ug, A02593-4-Biotin, A02593-4-Cy3, A02593-4-Dylight488, A02593-4-Dylight550, A02593-4-Dylight594, A02593-4-FITC, A02593-4-HRP, A02593-4-APC, A02593-4-PE, A02593-4-iFluor647, A02593-4-carrier-free
Alternative Names	ADAM metallopeptidase domain 15
Background	Disintegrin and metalloproteinase domain-containing protein 15 is an enzyme that in humans is encoded by the ADAM15 gene. This gene is mapped to 1q21.3. The protein encoded by this gene is a member of the ADAM (a disintegrin and metalloproteinase) protein family. ADAM family members are type I transmembrane glycoproteins known to be involved in cell adhesion and proteolytic ectodomain processing of cytokines and adhesion molecules. This protein contains multiple functional domains including a zinc-binding metalloprotease domain, a disintegrin-like domain, as well as a EGF-like domain. Through its disintegrin-like domain, this protein specifically interacts with the integrin beta chain, beta 3. It also interacts with Src family protein-tyrosine kinases in a phosphorylation-dependent manner, suggesting that this protein may function in cell-cell adhesion as well as in cellular signaling. Multiple alteatively spliced transcript variants encoding distinct isoforms have been observed.
Clonality	Polyclonal
Cross Reactivity	No cross-reactivity with other proteins.
Description	Boster Bio Anti-ADAM15 Antibody Picoband® catalog # A02593-4. Tested in ELISA, Flow Cytometry, WB applications. This antibody reacts with Human. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Weste blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.
Function	Active metalloproteinase with gelatinolytic and collagenolytic activity. Plays a role in the wound healing process. Mediates both heterotypic intraepithelial cell/T-cell interactions and homotypic T-cell aggregation. Inhibits beta-1 integrin-mediated cell
Host	Rabbit
Immunogen Region	E.coli-derived human ADAM15 recombinant protein (Position: R41-R456).
Isotype	Rabbit IgG
Molecular Weight	100 kDa
Reactivity	Human
Reconstitution	Add 0.2ml of distilled water will yield a concentration of 500ug/ml.
Specificity	No cross reactivity with other proteins.
Synonyms	Disintegrin and metalloproteinase domain-containing protein 15; ADAM 15; Metalloprotease RGD disintegrin protein; Metalloproteinase-like, disintegrin-like, and cysteine-rich protein 15; MDC-15; Metargidin; ADAM15; MDC15
Tissue Specificity	Expressed in colon and small intestine. Expressed in airway smooth muscle and glomerular mesangial cells (at protein level). Ubiquitously expressed. Overexpressed in atherosclerotic lesions. Constitutively expressed in cultured endothelium and smooth muscle. Expressed in chondrocytes. Expressed in airway smooth muscle and glomerular mesangial cells.
Note	Each vial contains 4mg Trehalose, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg NaN3.

Uniprot	Q13444
Gene Id	8751
Gene Name	ADAM15
Subcellular Location	Endomembrane system. Single-pass type I membrane protein. Adherens junction. Flagellum. Acrosome.

Conjugates	Biotin, Cy3, Dylight488, Dylight550, Dylight594, FITC, HRP, APC, PE, iFluor647, carrier-free

Concentration	Adding 0.2 ml of distilled water will yield a concentration of 500 ug/ml.
Form	Lyophilized
Purification	Immunogen affinity purified.
Storage	Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

Applications	ELISA, Flow Cytometry, WB
Description	Weste blot, 0.25-0.5ug/ml, Human<br> Flow Cytometry (Fixed), 1-3ug/1x10<sup>6</sup> cells, Human<br> ELISA, 0.1-0.5ug/ml, -<br>

Reference	1. Herren, B., Raines, E. W., Ross, R. Expression of a disintegrin-like protein in cultured human vascular cells and in vivo. FASEB J. 11: 173-180, 1997.<br /><br />2. Horiuchi, K., Weskamp, G., Lum, L., Hammes, H.-P., Cai, H., Brodie, T. A., Ludwig, T., Chiusaroli, R., Baron, R., Preissner, K. T., Manova, K., Blobel, C. P. Potential role for ADAM15 in pathological neovascularization in mice. Molec. Cell. Biol. 23: 5614-5624, 2003.<br /><br />3. Karkkainen, I., Karhu, R., Huovila, A.-P. J. Assignment of the ADAM15 gene to human chromosome band 1q21.3 by in situ hybridization. Cytogenet. Cell Genet. 88: 206-207, 2000.

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Combination SKU	Supplier No.	Conjugation	Size	Your price	Quantity
BHA21002492-1	A02593-4	-	100 ug	$370		Add to Cart
BHA21002492-2	A02593-4-10ug	Sample	10 ug	$99		Add to Cart
BHA21002492-3	A02593-4-Biotin	Biotin	100 ug	$570		Add to Cart
BHA21002492-4	A02593-4-Cy3	Cy3	100 ug	$570		Add to Cart
BHA21002492-5	A02593-4-Dylight488	Dylight488	100 ug	$570		Add to Cart
BHA21002492-6	A02593-4-Dylight550	Dylight550	100 ug	$570		Add to Cart
BHA21002492-7	A02593-4-Dylight594	Dylight594	100 ug	$570		Add to Cart
BHA21002492-8	A02593-4-FITC	FITC	100 ug	$570		Add to Cart
BHA21002492-9	A02593-4-HRP	HRP	100 ug	$570		Add to Cart
BHA21002492-10	A02593-4-APC	APC	100 ug	$670		Add to Cart
BHA21002492-11	A02593-4-PE	PE	100 ug	$670		Add to Cart
BHA21002492-12	A02593-4-iFluor647	iFluor647	100 ug	$670		Add to Cart
BHA21002492-13	A02593-4-carrier-free	carrier-free	100 ug	$370		Add to Cart

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