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Home / Primary Antibodies / Polyclonal Antibodies

Anti-ADAM10 Antibody Picoband®

SKU : BHA21004175

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Mfr.No.	A00566-5, A00566-5-10ug, A00566-5-Biotin, A00566-5-Cy3, A00566-5-Dylight488, A00566-5-Dylight550, A00566-5-Dylight594, A00566-5-FITC, A00566-5-HRP, A00566-5-APC, A00566-5-PE, A00566-5-iFluor647, A00566-5-carrier-free
Alternative Names	ADAM metallopeptidase domain 10
Background	A Disintegrin and metalloproteinase domain-containing protein 10, also known as ADAM10 or CDw156 or CD156c is a protein that in humans is encoded by the ADAM10 gene. Members of the ADAM family are cell surface proteins with a unique structure possessing both potential adhesion and protease domains. This gene encodes and ADAM family member that cleaves many proteins including TNF-alpha and E-cadherin. Alteate splicing results in multiple transcript variants encoding different proteins that may undergo similar processing.
Clonality	Polyclonal
Cross Reactivity	No cross-reactivity with other proteins.
Description	Boster Bio Anti-ADAM10 Antibody Picoband® catalog # A00566-5. Tested in ELISA, Flow Cytometry, WB applications. This antibody reacts with Human. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Weste blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.
Function	Cleaves the membrane-bound precursor of TNF-alpha at '76-Ala-\|-Val-77' to its mature soluble form. Responsible for the proteolytical release of soluble JAM3 from endothelial cells surface (PubMed:20592283). Responsible for the proteolytic release of sever
Host	Rabbit
Immunogen Region	E.coli-derived human ADAM10 recombinant protein (Position: A217-D311).
Isotype	Rabbit IgG
Molecular Weight	70 kDa
Reactivity	Human
Reconstitution	Adding 0.2 ml of distilled water will yield a concentration of 500 ug/ml.
Synonyms	Disintegrin and metalloproteinase domain-containing protein 10; ADAM 10; CDw156; Kuzbanian protein homolog; Mammalian disintegrin-metalloprotease; CD156c; ADAM10; KUZ; MADM
Tissue Specificity	Expressed in spleen, lymph node, thymus, peripheral blood leukocyte, bone marrow, cartilage, chondrocytes and fetal liver.
Note	Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.

Uniprot	O14672
Gene Id	102
Gene Name	ADAM10
Subcellular Location	Cell membrane.

Conjugates	Biotin, Cy3, Dylight488, Dylight550, Dylight594, FITC, HRP, APC, PE, iFluor647, carrier-free

Concentration	Adding 0.2 ml of distilled water will yield a concentration of 500 ug/ml.
Form	Lyophilized
Purification	Immunogen affinity purified.
Storage	At -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freezing and thawing.

Applications	WB, Flow Cytometry, ELISA
Description	Weste blot, 0.25-0.5 ug/ml, Human<br> Flow Cytometry (Fixed), 1-3 ug/1x10<sup>6</sup> cells, Human<br> ELISA, 0.1-0.5 ug/ml, -<br>

Reference	1. Abel, S., Hundhausen, C., Mentlein, R., Schulte, A., Berkhout, T. A., Broadway, N., Hartmann, D., Sedlacek, R., Dietrich, S., Muetze, B., Schuster, B., Kallen, K.-J., Saftig, P., Rose-John, S., Ludwig, A. The transmembrane CXC-chemokine ligand 16 is induced by IFN-gamma and TNF-alpha and shed by the activity of the disintegrin-like metalloproteinase ADAM10. J. Immun. 172: 6362-6372, 2004. <br /><br />2. Asai, M., Hattori, C., Szabo, B., Sasagawa, N., Maruyama, K., Tanuma, S., Ishiura, S. Putative function of ADAM9, ADAM10, and ADAM17 as APP alpha-secretase. Biochem. Biophys. Res. Commun. 301: 231-235, 2003. <br /><br />3. Atapattu, L., Saha, N., Chheang, C., Eissman, M. F., Xu, K., Vail, M. E., Hii, L., Llerena, C., Liu, Z., Horvay, K., Abud, H. E., Kusebauch, U., and 9 others. An activated form of ADAM10 is tumor selective and regulates cancer stem-like cells and tumor growth. J. Exp. Med. 213: 1741-1757, 2016.

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Combination SKU	Supplier No.	Conjugation	Size	Your price	Quantity
BHA21004175-1	A00566-5	-	100 ug	$370		Add to Cart
BHA21004175-2	A00566-5-10ug	Sample	10 ug	$99		Add to Cart
BHA21004175-3	A00566-5-Biotin	Biotin	100 ug	$570		Add to Cart
BHA21004175-4	A00566-5-Cy3	Cy3	100 ug	$570		Add to Cart
BHA21004175-5	A00566-5-Dylight488	Dylight488	100 ug	$570		Add to Cart
BHA21004175-6	A00566-5-Dylight550	Dylight550	100 ug	$570		Add to Cart
BHA21004175-7	A00566-5-Dylight594	Dylight594	100 ug	$570		Add to Cart
BHA21004175-8	A00566-5-FITC	FITC	100 ug	$570		Add to Cart
BHA21004175-9	A00566-5-HRP	HRP	100 ug	$570		Add to Cart
BHA21004175-10	A00566-5-APC	APC	100 ug	$670		Add to Cart
BHA21004175-11	A00566-5-PE	PE	100 ug	$670		Add to Cart
BHA21004175-12	A00566-5-iFluor647	iFluor647	100 ug	$670		Add to Cart
BHA21004175-13	A00566-5-carrier-free	carrier-free	100 ug	$370		Add to Cart

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