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Home / Primary Antibodies / Polyclonal Antibodies

Anti-ADAM10/ADAM10 Antibody Picoband®

SKU : BHA21006870

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Mfr.No.	PA1535, PA1535-10ug, PA1535-Biotin, PA1535-Cy3, PA1535-Dylight488, PA1535-Dylight550, PA1535-Dylight594, PA1535-FITC, PA1535-HRP, PA1535-APC, PA1535-PE, PA1535-iFluor647, PA1535-carrier-free
Alternative Names	Disintegrin and metalloproteinase domain-containing protein 10
Background	ADAM10, A Disintegrin and Metalloproteinase Domain 10, is also know as AD10. ADAM10 is a member of the ADAM family and members of this family are cell surface proteins with a unique structure possessing both potential adhesion and protease function. The ADAM10 gene is mapped to chromosome 15q21.3-q23. ADAM proteins contain an N-terminal signal sequence, followed by a prodomain, a metalloprotease-like domain, a disintegrin-like domain, a cysteine-rich region, an EGF -like repeat, a transmembrane domain, and a C-terminal cytoplasmic tail. Conversion of the membrane-bound precursor to a secreted mature protein is mediated by a protease termed TNFA convertase. ADAM10 possesses TNFA convertase activity.
Clonality	Polyclonal
Cross Reactivity	No cross-reactivity with other proteins
Description	Boster Bio Anti-ADAM10/ADAM10 Antibody catalog # PA1535. Tested in WB applications. This antibody reacts with Human. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Weste blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.
Function	Cleaves the membrane-bound precursor of TNF-alpha at '76-Ala-\|-Val-77' to its mature soluble form. Responsible for the proteolytical release of soluble JAM3 from endothelial cells surface. Responsible for the proteolytic release of several other cell-surf
Host	Rabbit
Immunogen Region	A synthetic peptide corresponding to a sequence at the C-terminus of human ADAM10.
Isotype	Rabbit IgG
Molecular Weight	31 kDa
Reactivity	Human
Reconstitution	Add 0.2ml of distilled water will yield a concentration of 500ug/ml.
Specificity	No cross reactivity with other proteins.
Synonyms	Disintegrin and metalloproteinase domain-containing protein 10;ADAM 10;3.4.24.81;CDw156;Kuzbanian protein homolog;Mammalian disintegrin-metalloprotease;CD156c;ADAM10;KUZ, MADM;
Tissue Specificity	Expressed in spleen, lymph node, thymus, peripheral blood leukocyte, bone marrow, cartilage, chondrocytes and fetal liver. .
Note	Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3.

Uniprot	O14672
Gene Name	ADAM10
Sequence	Contains 1 disintegrin domain.
Subcellular Location	Cell membrane; Single-pass type I membrane protein. Endomembrane system; Single-pass type I membrane protein. Is localized in the plasma membrane but is predominantly expressed in the Golgi apparatus and in released membrane vesicles derived likely from the Golgi.

Conjugates	Biotin, Cy3, Dylight488, Dylight550, Dylight594, FITC, HRP, APC, PE, iFluor647, carrier-free

Concentration	Adding 0.2 ml of distilled water will yield a concentration of 500 ug/ml.
Form	Lyophilized
Purification	Immunogen affinity purified.
Storage	Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

Applications	WB
Description	Weste blot, 0.1-0.5ug/ml, Human<br>

Reference	1. Wolfsberg, T. G., Primakoff, P., Myles, D. G., White, J. M.ADAM, a novel family of membrane proteins containing a disintegrin and metalloprotease domain: multipotential functions in cell-cell and cell-matrix interactions.J. Cell Biol. 131: 275-278, 1995.<br /><br />2. Yamazaki, K., Mizui, Y., Tanaka, I.Radiation hybrid mapping of human ADAM10 gene to chromosome 15.Genomics 45: 457-459, 1997.<br /><br />3. Lunn, C. A., Fan, X., Dalie, B., Miller, K., Zavodny, P. J., Narula, S. K., Lundell, D.Purification of ADAM 10 from bovine spleen as a TNFalpha convertase.FEBS Lett. 400: 333-335, 1997.<br /><br /><br /><br />

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Combination SKU	Supplier No.	Conjugation	Size	Your price	Quantity
BHA21006870-1	PA1535	-	100 ug	$370		Add to Cart
BHA21006870-2	PA1535-10ug	Sample	10 ug	$99		Add to Cart
BHA21006870-3	PA1535-Biotin	Biotin	100 ug	$570		Add to Cart
BHA21006870-4	PA1535-Cy3	Cy3	100 ug	$570		Add to Cart
BHA21006870-5	PA1535-Dylight488	Dylight488	100 ug	$570		Add to Cart
BHA21006870-6	PA1535-Dylight550	Dylight550	100 ug	$570		Add to Cart
BHA21006870-7	PA1535-Dylight594	Dylight594	100 ug	$570		Add to Cart
BHA21006870-8	PA1535-FITC	FITC	100 ug	$570		Add to Cart
BHA21006870-9	PA1535-HRP	HRP	100 ug	$570		Add to Cart
BHA21006870-10	PA1535-APC	APC	100 ug	$670		Add to Cart
BHA21006870-11	PA1535-PE	PE	100 ug	$670		Add to Cart
BHA21006870-12	PA1535-iFluor647	iFluor647	100 ug	$670		Add to Cart
BHA21006870-13	PA1535-carrier-free	carrier-free	100 ug	$370		Add to Cart

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