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Home / Primary Antibodies / Polyclonal Antibodies

Anti-ACTN2 Antibody Picoband®

SKU : BHA21003461

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Mfr.No.	A03673-1, A03673-1-10ug, A03673-1-Biotin, A03673-1-Cy3, A03673-1-Dylight488, A03673-1-Dylight550, A03673-1-Dylight594, A03673-1-FITC, A03673-1-HRP, A03673-1-APC, A03673-1-PE, A03673-1-iFluor647, A03673-1-carrier-free
Alternative Names	acetyl-CoA carboxylase beta
Background	Alpha-actinin 2 is a protein which in humans is encoded by the ACTN2 gene. Alpha actinins belong to the spectrin gene superfamily which represents a diverse group of cytoskeletal proteins, including the alpha and beta spectrins and dystrophins. Alpha actinin is an actin-binding protein with multiple roles in different cell types. In nonmuscle cells, the cytoskeletal isoform is found along microfilament bundles and adherens-type junctions, where it is involved in binding actin to the membrane. In contrast, skeletal, cardiac, and smooth muscle isoforms are localized to the Z-disc and analogous dense bodies, where they help anchor the myofibrillar actin filaments. This gene encodes a muscle-specific, alpha actinin isoform that is expressed in both skeletal and cardiac muscles. Several transcript variants encoding different isoforms have been found for this gene.
Clonality	Polyclonal
Cross Reactivity	No cross-reactivity with other proteins.
Description	Boster Bio Anti-ACTN2 Antibody Picoband® catalog # A03673-1. Tested in ELISA, Flow Cytometry, IHC, WB applications. This antibody reacts with Human, Mouse, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Weste blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.
Function	Catalyzes the ATP-dependent carboxylation of acetyl-CoA to malonyl-CoA (PubMed:20457939, PubMed:19236960, PubMed:20952656). Carries out three functions: biotin carboxyl carrier protein, biotin carboxylase and carboxyltransferase (PubMed:20457939, PubMed:1
Host	Rabbit
Immunogen Region	E.coli-derived human ACTN2 recombinant protein (Position: E567-E696).
Isotype	Rabbit IgG
Molecular Weight	104 kDa
Reactivity	Human, Mouse, Rat
Reconstitution	Adding 0.2 ml of distilled water will yield a concentration of 500 ug/ml.
Synonyms	Acetyl-CoA carboxylase 2; ACC-beta; Biotin carboxylase; ACACB; ACC2, ACCB
Tissue Specificity	Widely expressed with highest levels in heart, skeletal muscle, liver, adipose tissue, mammary gland, adrenal gland and colon (PubMed:9099716). Isoform 3 is expressed in skeletal muscle, adipose tissue and liver (at protein level) (PubMed:19190759). Isoform 3 is detected at high levels in adipose tissue with lower levels in heart, liver, skeletal muscle and testis (PubMed:19190759).
Note	Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.

Uniprot	P35609
Gene Id	88
Gene Name	ACTN2
Subcellular Location	Nucleus. Cytosol.

Conjugates	Biotin, Cy3, Dylight488, Dylight550, Dylight594, FITC, HRP, APC, PE, iFluor647, carrier-free

Concentration	Adding 0.2 ml of distilled water will yield a concentration of 500 ug/ml.
Form	Lyophilized
Purification	Immunogen affinity purified.
Storage	At -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freezing and thawing.

Applications	WB, IHC, Flow Cytometry, ELISA
Description	Weste blot, 0.25-0.5 ug/ml, Human, Mouse, Rat<br> Immunohistochemistry(Paraffin-embedded Section), 2-5 ug/ml, Mouse, Rat<br> Flow Cytometry (Fixed), 1-3 ug/1x10<sup>6</sup> cells, Human, Mouse<br> ELISA, 0.1-0.5 ug/ml, -<br>

Reference	1. Bagnall, R. D., Molloy, L. K., Kalman, J. M., Semsarian, C. Exome sequencing identifies a mutation in the ACTN2 gene in a family with idiopathic ventricular fibrillation, left ventricular noncompaction, and sudden death. BMC Med. Genet. 15: 99, 2014. Note: Electronic Article. <br /><br />2. Beggs, A. H., Byers, T. J., Knoll, J. H. M., Boyce, F. M., Bruns, G. A. P., Kunkel, L. M. Cloning and characterization of two human skeletal muscle alpha-actinin genes located on chromosomes 1 and 11. J. Biol. Chem. 267: 9281-9288, 1992. <br /><br />3. Beggs, A. H., Phillips, H. A., Kozman, H., Mulley, J. C., Wilton, S. D., Kunkel, L. M., Laing, N. G. A (CA)n repeat polymorphism for the human skeletal muscle alpha-actinin gene ACTN2 and its localization on the linkage map of chromosome 1. Genomics 13: 1314-1315, 1992.

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Combination SKU	Supplier No.	Conjugation	Size	Your price	Quantity
BHA21003461-1	A03673-1	-	100 ug	$370		Add to Cart
BHA21003461-2	A03673-1-10ug	Sample	10 ug	$99		Add to Cart
BHA21003461-3	A03673-1-Biotin	Biotin	100 ug	$570		Add to Cart
BHA21003461-4	A03673-1-Cy3	Cy3	100 ug	$570		Add to Cart
BHA21003461-5	A03673-1-Dylight488	Dylight488	100 ug	$570		Add to Cart
BHA21003461-6	A03673-1-Dylight550	Dylight550	100 ug	$570		Add to Cart
BHA21003461-7	A03673-1-Dylight594	Dylight594	100 ug	$570		Add to Cart
BHA21003461-8	A03673-1-FITC	FITC	100 ug	$570		Add to Cart
BHA21003461-9	A03673-1-HRP	HRP	100 ug	$570		Add to Cart
BHA21003461-10	A03673-1-APC	APC	100 ug	$670		Add to Cart
BHA21003461-11	A03673-1-PE	PE	100 ug	$670		Add to Cart
BHA21003461-12	A03673-1-iFluor647	iFluor647	100 ug	$670		Add to Cart
BHA21003461-13	A03673-1-carrier-free	carrier-free	100 ug	$370		Add to Cart

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