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Home / Primary Antibodies / Polyclonal Antibodies

Anti-ACTH/POMC Antibody

SKU : BHA21007501

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Mfr.No.	PB9039, PB9039-10ug, PB9039-Biotin, PB9039-Cy3, PB9039-Dylight488, PB9039-Dylight550, PB9039-Dylight594, PB9039-FITC, PB9039-HRP, PB9039-APC, PB9039-PE, PB9039-iFluor647, PB9039-carrier-free
Alternative Names	Pro-opiomelanocortin
Background	Adrenocorticotropic hormone (ACTH), also known as corticotropin, is a polypeptide tropic hormone produced and secreted by the anterior pituitary gland. It is an important component of the hypothalamic-pituitary-adrenal axis and is often produced in response to biological stress (along with its precursor corticotropin-releasing hormone from the hypothalamus). Its principal effects are increased production and release of corticosteroids. ACTH stimulates secretion of glucocorticoid steroid hormones from adrenal cortex cells, especially in the zona fasciculata of the adrenal glands. This gene can influence steroid hormone secretion by both rapid short-term mechanisms that take place within minutes and slower long-term actions. Besides, ACTH also enhances transcription of mitochondrial genes that encode for subunits of mitochondrial oxidative phosphorylation systems.
Clonality	Polyclonal
Cross Reactivity	No cross-reactivity with other proteins
Description	Boster Bio Anti-ACTH/POMC Antibody Picoband® catalog # PB9039. Tested in IHC applications. This antibody reacts with Human, Mouse, Rat.
Function	ACTH stimulates the adrenal glands to release cortisol.
Host	Rabbit
Immunogen Region	A synthetic peptide corresponding to a sequence in the middle region of human ACTH, different from the related mouse and rat sequences by two amino acids.
Isotype	Rabbit IgG
Molecular Weight	30 kDa
Reactivity	Human, Mouse, Rat
Reconstitution	Add 0.2ml of distilled water will yield a concentration of 500ug/ml.
Specificity	No cross reactivity with other proteins.
Synonyms	Pro-opiomelanocortin;POMC;Corticotropin-lipotropin;NPP;Melanotropin gamma;Gamma-MSH;Potential peptide;Corticotropin;Adrenocorticotropic hormone;ACTH;Melanotropin alpha;Alpha-MSH;Corticotropin-like intermediary peptide;CLIP;Lipotropin beta;Beta-LPH;Lipotropin gamma;Gamma-LPH;Melanotropin beta;Beta-MSH;Beta-endorphin;Met-enkephalin;POMC;
Tissue Specificity	ACTH and MSH are produced by the pituitary gland.
Note	Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg NaN3.

Uniprot	P01189
Gene Id	5443
Gene Name	POMC
Sequence	Belongs to the POMC family.
Subcellular Location	Secreted.

Conjugates	Biotin, Cy3, Dylight488, Dylight550, Dylight594, FITC, HRP, APC, PE, iFluor647, carrier-free

Concentration	Adding 0.2 ml of distilled water will yield a concentration of 500 ug/ml.
Form	Lyophilized
Purification	Immunogen affinity purified.
Storage	Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

Applications	IHC
Description	Immunohistochemistry (Paraffin-embedded Section), 0.5-1ug/ml, Mouse, Rat, Human, By Heat

Reference	1. Dibner, Chaa; Schibler, Ueli; Albrecht, Urs (2010). "The Mammalian Circadian Timing System: Organization and Coordination of Central and Peripheral Clocks". Annual Review of Physiology72: 517549. 2. Hanukoglu I, Feuchtwanger R, Hanukoglu A (November 1990). "Mechanism of corticotropin and cAMP induction of mitochondrial cytochrome P450 system enzymes in adrenal cortex cells". J. Biol. Chem. 265 (33): 206028. 3. Raikhinstein M, Zohar M, Hanukoglu I (February 1994). "cDNA cloning and sequence analysis of the bovine adrenocorticotropic hormone (ACTH) receptor". Biochim. Biophys. Acta 1220 (3): 32932.

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Combination SKU	Supplier No.	Conjugation	Size	Your price	Quantity
BHA21007501-1	PB9039	-	100 ug	$370		Add to Cart
BHA21007501-2	PB9039-10ug	Sample	10 ug	$99		Add to Cart
BHA21007501-3	PB9039-Biotin	Biotin	100 ug	$570		Add to Cart
BHA21007501-4	PB9039-Cy3	Cy3	100 ug	$570		Add to Cart
BHA21007501-5	PB9039-Dylight488	Dylight488	100 ug	$570		Add to Cart
BHA21007501-6	PB9039-Dylight550	Dylight550	100 ug	$570		Add to Cart
BHA21007501-7	PB9039-Dylight594	Dylight594	100 ug	$570		Add to Cart
BHA21007501-8	PB9039-FITC	FITC	100 ug	$570		Add to Cart
BHA21007501-9	PB9039-HRP	HRP	100 ug	$570		Add to Cart
BHA21007501-10	PB9039-APC	APC	100 ug	$670		Add to Cart
BHA21007501-11	PB9039-PE	PE	100 ug	$670		Add to Cart
BHA21007501-12	PB9039-iFluor647	iFluor647	100 ug	$670		Add to Cart
BHA21007501-13	PB9039-carrier-free	carrier-free	100 ug	$370		Add to Cart

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