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Home / Primary Antibodies / Polyclonal Antibodies

Anti-ACE Antibody Picoband®

SKU : BHA21006338

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Mfr.No.	A00251-3, A00251-3-10ug, A00251-3-Biotin, A00251-3-Cy3, A00251-3-Dylight488, A00251-3-Dylight550, A00251-3-Dylight594, A00251-3-FITC, A00251-3-HRP, A00251-3-APC, A00251-3-PE, A00251-3-iFluor647, A00251-3-carrier-free
Background	This gene encodes an enzyme involved in blood pressure regulation and electrolyte balance. It catalyzes the conversion of angiotensin I into a physiologically active peptide angiotensin II. Angiotensin II is a potent vasopressor and aldosterone-stimulating peptide that controls blood pressure and fluid-electrolyte balance. This angiotensin converting enzyme (ACE) also inactivates the vasodilator protein, bradykinin. Accordingly, the encoded enzyme increases blood pressure and is a drug target of ACE inhibitors, which are often prescribed to reduce blood pressure. This enzyme additionally plays a role in fertility through its ability to cleave and release GPI-anchored membrane proteins in spermatozoa. Many studies have associated the presence or absence of a 287 bp Alu repeat element in this gene with the levels of circulating enzyme. This polymorphism, as well as mutations in this gene, have been implicated in a wide variety of diseases including cardiovascular pathophysiologies, psoriasis, renal disease, stroke, and Alzheimer's disease. Regulation of the homologous ACE2 gene may be involved in progression of disease caused by several human coronaviruses, including SARS-CoV and SARS-CoV-2. Alteative splicing results in multiple transcript variants encoding both somatic (sACE) and male-specific testicular (tACE) isoforms.
Clonality	Polyclonal
Description	Boster Bio Anti-ACE Antibody Picoband® catalog # A00251-3. Tested in WB, IHC, Flow Cytometry, ELISA applications. This antibody reacts with Human, Mouse, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Weste blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.
Host	Rabbit
Immunogen Region	E.coli-derived human ACE recombinant protein (Position: R149-C545). Human ACE shares 90.4% and 91.4% amino acid (aa) sequence identity with mouse and rat ACE, respectively.
Molecular Weight	150-180 kDa
Reactivity	Human, Mouse, Rat
Reconstitution	Adding 0.2 ml of distilled water will yield a concentration of 500 ug/ml.
Note	Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.

Uniprot	P12821
Gene Id	1636
Gene Name	ACE

Conjugates	Biotin, Cy3, Dylight488, Dylight550, Dylight594, FITC, HRP, APC, PE, iFluor647, carrier-free

Concentration	Adding 0.2 ml of distilled water will yield a concentration of 500 ug/ml.
Form	Lyophilized
Purification	Immunogen affinity purified.
Storage	At -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months.Avoid repeated freezing and thawing.

Applications	WB, IHC, ELISA
Description	Weste blot, 0.25-0.5 ug/ml, Mouse, Rat Immunohistochemistry, 2-5 ug/ml, Human, Mouse ELISA, 0.1-0.5 ug/ml, -

Reference	1. Alfalah, M., Parkin, E. T., Jacob, R., Sturrock, E. D., Mentele, R., Tuer, A. J., Hooper, N. M., Naim, H. Y. A point mutation in the juxtamembrane stalk of human angiotensin I-converting enzyme invokes the action of a distinct secretase. J. Biol. Chem. 276: 21105-21109, 2001. 2. Amant, C., Bauters, C., Bodart, J.-C., Lablanche, J.-M., Grollier, G., Danchin, N., Hamon, M., Richard, F., Helbecque, N., McFadden, E. P., Amouyel, P., Bertrand, M. E. D allele of the angiotensin I-converting enzyme is a major risk factor for restenosis after coronary stenting. Circulation 96: 56-60, 1997. 3. Arbustini, E., Grasso, M., Fasani, R., Klersy, C., Diegoli, M., Porcu, E., Banchieri, N., Fortina, P., Danesino, C., Specchia, G. Angiotensin converting enzyme gene deletion allele is independently and strongly associated with coronary atherosclerosis and myocardial infarction. Brit. Heart J. 74: 584-591, 1995.

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Combination SKU	Supplier No.	Conjugation	Size	Your price	Quantity
BHA21006338-1	A00251-3	-	100 ug	$370		Add to Cart
BHA21006338-2	A00251-3-10ug	Sample	10 ug	$99		Add to Cart
BHA21006338-3	A00251-3-Biotin	Biotin	100 ug	$570		Add to Cart
BHA21006338-4	A00251-3-Cy3	Cy3	100 ug	$570		Add to Cart
BHA21006338-5	A00251-3-Dylight488	Dylight488	100 ug	$570		Add to Cart
BHA21006338-6	A00251-3-Dylight550	Dylight550	100 ug	$570		Add to Cart
BHA21006338-7	A00251-3-Dylight594	Dylight594	100 ug	$570		Add to Cart
BHA21006338-8	A00251-3-FITC	FITC	100 ug	$570		Add to Cart
BHA21006338-9	A00251-3-HRP	HRP	100 ug	$570		Add to Cart
BHA21006338-10	A00251-3-APC	APC	100 ug	$670		Add to Cart
BHA21006338-11	A00251-3-PE	PE	100 ug	$670		Add to Cart
BHA21006338-12	A00251-3-iFluor647	iFluor647	100 ug	$670		Add to Cart
BHA21006338-13	A00251-3-carrier-free	carrier-free	100 ug	$370		Add to Cart

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