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Home / Primary Antibodies / Polyclonal Antibodies

Anti-ABCG5 Antibody Picoband®

SKU : BHA21007128

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Mfr.No.	PA1871, PA1871-10ug, PA1871-Biotin, PA1871-Cy3, PA1871-Dylight488, PA1871-Dylight550, PA1871-Dylight594, PA1871-FITC, PA1871-HRP, PA1871-APC, PA1871-PE, PA1871-iFluor647, PA1871-carrier-free
Alternative Names	ATP-binding cassette sub-family G member 5
Background	ABCG5 (Atp-binding cassette, subfamily g, member 5) also known as STEROLIN 1, is a protein that in humans is encoded by the ABCG5 gene. The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. This protein is a member of the White subfamily. The protein encoded by this gene functions as a half-transporter to limit intestinal absorption and promote biliary excretion of sterols. The ABCG5 gene contains 13 exons and spans about 28 kb.The ABCG5 gene is mapped on 2p21. It is expressed in a tissue-specific manner in the liver, colon, and intestine. This gene is tandemly arrayed on chromosome 2, in a head-to-head orientation with family member ABCG8. Mutations in this gene may contribute to sterol accumulation and atheroschlerosis, and have been observed in patients with sitosterolemia. Small (2003) reviewed the role of ABC transporters in secretion of cholesterol from liver into bile, particularly the role of ABCG5/ABCG8.The ABCG5 and ABCG8 genes are an example of closely neighboring genes in a head-to-head orientation that, when mutated, cause the same phenotype.
Clonality	Polyclonal
Cross Reactivity	No cross-reactivity with other proteins
Description	Boster Bio Anti-ABCG5 Antibody catalog # PA1871. Tested in Flow Cytometry, IHC, ICC, WB applications. This antibody reacts with Human. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Weste blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.
Function	Transporter that appears to play an indispensable role in the selective transport of the dietary cholesterol in and out of the enterocytes and in the selective sterol excretion by the liver into bile.
Host	Rabbit
Immunogen Region	A synthetic peptide corresponding to a sequence at the N-terminus of human ABCG5.
Isotype	Rabbit IgG
Molecular Weight	73 kDa
Reactivity	Human
Reconstitution	Add 0.2ml of distilled water will yield a concentration of 500ug/ml.
Specificity	No cross reactivity with other proteins.
Synonyms	ATP-binding cassette sub-family G member 5;Sterolin-1;ABCG5;
Tissue Specificity	Strongly expressed in the liver, lower levels in the small intestine and colon.
Note	Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3.

Uniprot	Q9H222
Gene Name	ABCG5
Sequence	Belongs to the ABC transporter superfamily. ABCG family. Eye pigment precursor importer (TC 3.A.1.204) subfamily.
Subcellular Location	Membrane ; Multi-pass membrane protein .

Conjugates	Biotin, Cy3, Dylight488, Dylight550, Dylight594, FITC, HRP, APC, PE, iFluor647, carrier-free

Concentration	Adding 0.2 ml of distilled water will yield a concentration of 500 ug/ml.
Form	Lyophilized
Purification	Immunogen affinity purified.
Storage	Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

Applications	Flow Cytometry, IHC, ICC, WB
Description	Weste blot, 0.1-0.5ug/ml, Human<br>Immunohistochemistry (Frozen Section), 0.5-1ug/ml, Human<br> Immunocytochemistry, 0.5-1ug/ml, Human<br> Flow Cytometry (Fixed), 1-3ug/1x10<sup>6</sup> cells, Human

Reference	1. Lee, M.-H., Lu, K., Hazard, S., Yu, H., Shulenin, S., Hidaka, H., Kojima, H., Allikmets, R., Sakuma, N., Pegoraro, R., Srivastava, A. K., Salen, G., Dean, M., Patel, S. B. Identification of a gene, ABCG5, important in the regulation of dietary cholesterol absorption. Nature Genet. 27: 79-83, 2001.<br /><br />2. Lu, K., Lee, M. H., Yu, H., Zhou, Y., Sandell, S. A., Salen, G., Patel, S. B. Molecular cloning, genomic organization, genetic variations, and characterization of murine sterolin genes Abcg5and Abcg8. J. Lipid Res. 43: 565-578, 2002.<br /><br />3. Small, D. M. Role of ABC transporters in secretion of cholesterol from liver into bile. (Commentary)Proc. Nat. Acad. Sci. 100: 4-6, 2003.<br /><br />

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Combination SKU	Supplier No.	Conjugation	Size	Your price	Quantity
BHA21007128-1	PA1871	-	100 ug	$370		Add to Cart
BHA21007128-2	PA1871-10ug	Sample	10 ug	$99		Add to Cart
BHA21007128-3	PA1871-Biotin	Biotin	100 ug	$570		Add to Cart
BHA21007128-4	PA1871-Cy3	Cy3	100 ug	$570		Add to Cart
BHA21007128-5	PA1871-Dylight488	Dylight488	100 ug	$570		Add to Cart
BHA21007128-6	PA1871-Dylight550	Dylight550	100 ug	$570		Add to Cart
BHA21007128-7	PA1871-Dylight594	Dylight594	100 ug	$570		Add to Cart
BHA21007128-8	PA1871-FITC	FITC	100 ug	$570		Add to Cart
BHA21007128-9	PA1871-HRP	HRP	100 ug	$570		Add to Cart
BHA21007128-10	PA1871-APC	APC	100 ug	$670		Add to Cart
BHA21007128-11	PA1871-PE	PE	100 ug	$670		Add to Cart
BHA21007128-12	PA1871-iFluor647	iFluor647	100 ug	$670		Add to Cart
BHA21007128-13	PA1871-carrier-free	carrier-free	100 ug	$370		Add to Cart

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