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Home / Primary Antibodies / Polyclonal Antibodies

Anti-ABCA4 Antibody Picoband®

SKU : BHA21007276

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Mfr.No.	PA2066, PA2066-10ug, PA2066-Biotin, PA2066-Cy3, PA2066-Dylight488, PA2066-Dylight550, PA2066-Dylight594, PA2066-FITC, PA2066-HRP, PA2066-APC, PA2066-PE, PA2066-iFluor647, PA2066-carrier-free
Alternative Names	Retinal-specific ATP-binding cassette transporter
Background	ABCA4 (ATP-Binding Cassette, Subfamily A, Member 4), also known as ABCR, is a protein which in humans is encoded by the ABCA4 gene. ABCA4 is a member of the ATP-binding cassette transporter gene sub-family A (ABC1) found exclusively in multicellular eukaryotes. Using a whole genome radiation hybrid panel, Allikmets et al. (1997) mapped the ABCR gene to 1p21-p13. Allikmets et al. (1997) localized ABCR transcripts exclusively within photoreceptor cells, indicating that ABCR mediates the transport of an essential molecule (or ion) either into or out of photoreceptor cells. Molday et al. (2000) showed by immunofluorescence microscopy and Weste blot analysis that ABCR is present in foveal and peripheral cone, as well as rod, photoreceptors. The results suggested that the loss in central vision experienced by patients with Stargardt macular dystrophy arises ly from ABCR-mediated foveal cone degeneration.
Clonality	Polyclonal
Cross Reactivity	No cross-reactivity with other proteins
Description	Boster Bio Anti-ABCA4 Antibody catalog # PA2066. Tested in WB applications. This antibody reacts with Mouse. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Weste blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.
Function	In the visual cycle, acts as an inward-ed retinoid flipase, retinoid substrates imported by ABCA4 from the extracellular or intradiscal (rod) membrane surfaces to the cytoplasmic membrane surface are all-trans-retinaldehyde (ATR) and N-retinyl-phosphatidy
Host	Rabbit
Immunogen Region	A synthetic peptide corresponding to a sequence at the C-terminus of mouse ABCA4, identical to the related rat sequence.
Isotype	Rabbit IgG
Molecular Weight	280 kDa
Reactivity	Mouse
Reconstitution	Add 0.2ml of distilled water will yield a concentration of 500ug/ml.
Specificity	No cross reactivity with other proteins.
Synonyms	Retinal-specific ATP-binding cassette transporter;ATP-binding cassette sub-family A member 4;RIM ABC transporter;RIM protein;RmP;Abca4;Abcr;
Tissue Specificity	Retinal-specific. Seems to be exclusively found in the rims of rod photoreceptor cells.
Note	Each vial contains 4 mg Trehalose, 0.9 mg NaCl and 0.2mg Na2HPO4.

Uniprot	O35600
Gene Name	ABCA4
Sequence	Belongs to the ABC transporter superfamily. ABCA family.
Subcellular Location	Membrane ; Multi-pass membrane protein . Localized to outer segment disk edges of rods and cones, with around one million copies/photoreceptor. .

Conjugates	Biotin, Cy3, Dylight488, Dylight550, Dylight594, FITC, HRP, APC, PE, iFluor647, carrier-free

Concentration	Adding 0.2 ml of distilled water will yield a concentration of 500 ug/ml.
Form	Lyophilized
Purification	Immunogen affinity purified.
Storage	Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

Applications	WB
Description	Weste blot, 0.1-0.5ug/ml, Mouse<br>

Reference	1. Allikmets, R., Shroyer, N. F., Singh, N., Seddon, J. M., Lewis, R. A., Bestein, P. S., Peiffer, A., Zabriskie, N. A., Hutchinson, A., Dean, M., Lupski, J. R., Leppert, M. Mutation of the Stargardt disease gene (ABCR) in age-related macular degeneration. Science 277: 1805-1807, 1997.<br /><br />2. Allikmets, R., Singh, N., Sun, H., Shroyer, N. F., Hutchinson, A., Chidambaram, A., Gerrard, B., Baird, L., Stauffer, D., Peiffer, A., Rattner, A., Smallwood, P., Li, Y., Anderson, K. L., Lewis, R. A., Nathans, J., Leppert, M., Dean, M., Lupski, J. R. A photoreceptor cell-specific ATP-binding transporter gene (ABCR) is mutated in recessive Stargardt macular dystrophy. Nature Genet. 15: 236-246, 1997. Note: Erratum: Nature Genet. 17:122 only, 1997.<br /><br />3. Molday, L. L., Rabin, A. R., Molday, R. S. ABCR expression in foveal cone photoreceptors and its role in Stargardt macular dystrophy. Nature Genet. 25: 257-258, 2000.<br /><br />

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Combination SKU	Supplier No.	Conjugation	Size	Your price	Quantity
BHA21007276-1	PA2066	-	100 ug	$370		Add to Cart
BHA21007276-2	PA2066-10ug	Sample	10 ug	$99		Add to Cart
BHA21007276-3	PA2066-Biotin	Biotin	100 ug	$570		Add to Cart
BHA21007276-4	PA2066-Cy3	Cy3	100 ug	$570		Add to Cart
BHA21007276-5	PA2066-Dylight488	Dylight488	100 ug	$570		Add to Cart
BHA21007276-6	PA2066-Dylight550	Dylight550	100 ug	$570		Add to Cart
BHA21007276-7	PA2066-Dylight594	Dylight594	100 ug	$570		Add to Cart
BHA21007276-8	PA2066-FITC	FITC	100 ug	$570		Add to Cart
BHA21007276-9	PA2066-HRP	HRP	100 ug	$570		Add to Cart
BHA21007276-10	PA2066-APC	APC	100 ug	$670		Add to Cart
BHA21007276-11	PA2066-PE	PE	100 ug	$670		Add to Cart
BHA21007276-12	PA2066-iFluor647	iFluor647	100 ug	$670		Add to Cart
BHA21007276-13	PA2066-carrier-free	carrier-free	100 ug	$370		Add to Cart

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