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Home / Primary Antibodies / Polyclonal Antibodies

Anti-AACT/SERPINA3 Antibody Picoband®

SKU : BHA21007403

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Mfr.No.	PA2217, PA2217-10ug, PA2217-Biotin, PA2217-Cy3, PA2217-Dylight488, PA2217-Dylight550, PA2217-Dylight594, PA2217-FITC, PA2217-HRP, PA2217-APC, PA2217-PE, PA2217-iFluor647, PA2217-carrier-free
Alternative Names	Alpha-1-antichymotrypsin
Background	Alpha 1-antichymotrypsin, also called serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3 or GIG24 is an alpha globulin glycoprotein that is a member of the serpin superfamily. In humans, it is encoded by the SERPINA3 gene. This gene is mapped to 14q32.13. The protein encoded by this gene is a plasma protease inhibitor and member of the serine protease inhibitor class. Polymorphisms in this protein appear to be tissue specific and influence protease targeting. Variations in this protein's sequence have been implicated in Alzheimer's disease, and deficiency of this protein has been associated with liver disease. Mutations have been identified in patients with Parkinson disease and chronic obstructive pulmonary disease.
Clonality	Polyclonal
Cross Reactivity	No cross-reactivity with other proteins
Description	Boster Bio Anti-AACT/SERPINA3 Antibody catalog # PA2217. Tested in IHC, WB applications. This antibody reacts with Human. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Weste blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.
Function	Although its physiological function is unclear, it can inhibit neutrophil cathepsin G and mast cell chymase, both of which can convert angiotensin-1 to the active angiotensin-2. .
Host	Rabbit
Immunogen Region	A synthetic peptide corresponding to a sequence in the middle region of human alpha 1 Antichymotrypsin.
Isotype	Rabbit IgG
Molecular Weight	57 kDa
Reactivity	Human
Reconstitution	Add 0.2ml of distilled water will yield a concentration of 500ug/ml.
Specificity	No cross reactivity with other proteins.
Synonyms	Alpha-1-antichymotrypsin;ACT;Cell growth-inhibiting gene 24/25 protein;Serpin A3;Alpha-1-antichymotrypsin His-Pro-less;SERPINA3;AACT;GIG24, GIG25;
Tissue Specificity	Plasma. Synthesized in the liver. Like the related alpha-1-antitrypsin, its concentration increases in the acute phase of inflammation or infection. Found in the amyloid plaques from the hippocampus of Alzheimer disease brains. .
Note	Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3.

Uniprot	P01011
Gene Name	SERPINA3
Sequence	Belongs to the serpin family.
Subcellular Location	Secreted.

Conjugates	Biotin, Cy3, Dylight488, Dylight550, Dylight594, FITC, HRP, APC, PE, iFluor647, carrier-free

Concentration	Adding 0.2 ml of distilled water will yield a concentration of 500 ug/ml.
Form	Lyophilized
Purification	Immunogen affinity purified.
Storage	Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

Applications	IHC, WB
Description	Immunohistochemistry (Paraffin-embedded Section), 0.5-1ug/ml, Human, By Heat<br>Weste blot, 0.1-0.5ug/ml, Human<br>

Reference	1. Chappell, S., Daly, L., Morgan, K., Baranes, T. G., Roca, J., Rabinovich, R., Millar, A., Donnelly, S. C., Keatings, V., MacNee, W., Stolk, J., Hiemstra, P., Miniati, M., Monti, S., O'Connor, C. M., Kalsheker, N. Cryptic haplotypes of SERPINA1 confer susceptibility to chronic obstructive pulmonary disease. Hum. Mutat. 27: 103-109, 2006.<br /><br />2. Wang, X., DeKosky, S. T., Luedecking-Zimmer, E., Ganguli, M., Kamboh, M. I. Genetic variation in alpha-1-antichymotrypsin and its association with Alzheimer's disease. Hum. Genet. 110: 356-365, 2002.<br /><br />

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Combination SKU	Supplier No.	Conjugation	Size	Your price	Quantity
BHA21007403-1	PA2217	-	100 ug	$370		Add to Cart
BHA21007403-2	PA2217-10ug	Sample	10 ug	$99		Add to Cart
BHA21007403-3	PA2217-Biotin	Biotin	100 ug	$570		Add to Cart
BHA21007403-4	PA2217-Cy3	Cy3	100 ug	$570		Add to Cart
BHA21007403-5	PA2217-Dylight488	Dylight488	100 ug	$570		Add to Cart
BHA21007403-6	PA2217-Dylight550	Dylight550	100 ug	$570		Add to Cart
BHA21007403-7	PA2217-Dylight594	Dylight594	100 ug	$570		Add to Cart
BHA21007403-8	PA2217-FITC	FITC	100 ug	$570		Add to Cart
BHA21007403-9	PA2217-HRP	HRP	100 ug	$570		Add to Cart
BHA21007403-10	PA2217-APC	APC	100 ug	$670		Add to Cart
BHA21007403-11	PA2217-PE	PE	100 ug	$670		Add to Cart
BHA21007403-12	PA2217-iFluor647	iFluor647	100 ug	$670		Add to Cart
BHA21007403-13	PA2217-carrier-free	carrier-free	100 ug	$370		Add to Cart

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