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Home / Primary Antibodies / Polyclonal Antibodies

Anti-5HT2B Receptor/HTR2B Antibody Picoband®

SKU : BHA21000496

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Mfr.No.	PB9600, PB9600-10ug, PB9600-Biotin, PB9600-Cy3, PB9600-Dylight488, PB9600-Dylight550, PB9600-Dylight594, PB9600-FITC, PB9600-HRP, PB9600-APC, PB9600-PE, PB9600-iFluor647, PB9600-carrier-free
Alternative Names	5-hydroxytryptamine receptor 2B
Background	5HT2B Receptor is known as HTR2B. This gene encodes one of the several different receptors for 5-hydroxytryptamine (serotonin) that belongs to the G-protein coupled receptor 1 family. Serotonin is a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. Serotonin receptors mediate many of the central and peripheral physiologic functions of serotonin, including regulation of cardiovascular functions and impulsive behavior. Population and family-based analyses of a minor allele (glutamine-to-stop substitution, designated Q20*) which blocks expression of this protein, and knockout studies in mice, suggest a role for this gene in impulsivity. However, other factors, such as elevated testosterone levels, may also be involved.
Clonality	Polyclonal
Cross Reactivity	No cross-reactivity with other proteins
Description	Boster Bio Anti-5HT2B Receptor/HTR2B Antibody Picoband® catalog # PB9600. Tested in WB applications. This antibody reacts with Human, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Weste blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.
Function	G-protein coupled receptor for 5-hydroxytryptamine (serotonin). Also functions as a receptor for various ergot alkaloid derivatives and psychoactive substances. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-bin
Host	Rabbit
Immunogen Region	A synthetic peptide corresponding to a sequence at the C-terminus of human 5HT2B Receptor, different from the related mouse sequence by six amino acids, and from the related rat sequence by nine amino acids.
Isotype	Rabbit IgG
Molecular Weight	54 kDa
Reactivity	Human, Rat
Reconstitution	Add 0.2ml of distilled water will yield a concentration of 500ug/ml.
Specificity	No cross reactivity with other proteins.
Synonyms	5-hydroxytryptamine receptor 2B;5-HT-2B;5-HT2B;Serotonin receptor 2B;HTR2B;
Tissue Specificity	Ubiquitous. Detected in liver, kidney, heart, pulmonary artery, and intestine. Detected at lower levels in blood, placenta and brain, especially in cerebellum, occipital cortex and frontal cortex. .
Note	Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg NaN3.

Uniprot	P41595
Gene Id	3357
Gene Name	HTR2B
Sequence	Belongs to the G-protein coupled receptor 1 family.
Subcellular Location	Cell membrane; Multi-pass membrane protein. Cell junction, synapse, synaptosome .

Conjugates	Biotin, Cy3, Dylight488, Dylight550, Dylight594, FITC, HRP, APC, PE, iFluor647, carrier-free

Concentration	Adding 0.2 ml of distilled water will yield a concentration of 500 ug/ml.
Form	Lyophilized
Purification	Immunogen affinity purified.
Storage	Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

Applications	WB
Description	Weste blot, 0.1-0.5ug/ml, Human, Rat

Reference	1. "Entrez Gene: HTR2B 5-hydroxytryptamine (serotonin) receptor 2B". 2. Doly S, Valjent E, Setola V, Callebert J, Hervé D, Launay JM, Maroteaux L (Mar 2008). "Serotonin 5-HT2B receptors are required for 3,4-methylenedioxymethamphetamine-induced hyperlocomotion and 5-HT release in vivo and in vitro". The Joual of Neuroscience28 (11): 293340. 3. Schmuck K, Ullmer C, Engels P, Lübbert H (Mar 1994). "Cloning and functional characterization of the human 5-HT2B serotonin receptor". FEBS Letters 342 (1): 8590.

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Combination SKU	Supplier No.	Size	Conjugation	Your price	Quantity
BHA21000496-1	PB9600	100 ug	-	$370		Add to Cart
BHA21000496-2	PB9600-10ug	10 ug	Sample	$99		Add to Cart
BHA21000496-3	PB9600-Biotin	100 ug	Biotin	$570		Add to Cart
BHA21000496-4	PB9600-Cy3	100 ug	Cy3	$570		Add to Cart
BHA21000496-5	PB9600-Dylight488	100 ug	Dylight488	$570		Add to Cart
BHA21000496-6	PB9600-Dylight550	100 ug	Dylight550	$570		Add to Cart
BHA21000496-7	PB9600-Dylight594	100 ug	Dylight594	$570		Add to Cart
BHA21000496-8	PB9600-FITC	100 ug	FITC	$570		Add to Cart
BHA21000496-9	PB9600-HRP	100 ug	HRP	$570		Add to Cart
BHA21000496-10	PB9600-APC	100 ug	APC	$670		Add to Cart
BHA21000496-11	PB9600-PE	100 ug	PE	$670		Add to Cart
BHA21000496-12	PB9600-iFluor647	100 ug	iFluor647	$670		Add to Cart
BHA21000496-13	PB9600-carrier-free	100 ug	carrier-free	$370		Add to Cart

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