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Home / Primary Antibodies / Polyclonal Antibodies

Anti-5HT1A Receptor/HTR1A Antibody Picoband®

SKU : BHA21006954

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Mfr.No.	PA1647, PA1647-10ug, PA1647-Biotin, PA1647-Cy3, PA1647-Dylight488, PA1647-Dylight550, PA1647-Dylight594, PA1647-FITC, PA1647-HRP, PA1647-APC, PA1647-PE, PA1647-iFluor647, PA1647-carrier-free
Alternative Names	5-hydroxytryptamine receptor 1A
Background	HTR1A (5-HYDROXYTRYPTAMINE RECEPTOR 1A), also called SEROTONIN 5-HT-1A RECEPTOR or BETA-2-ADRENERGIC RECEPTOR-LIKE PROTEIN G-21, is a subtype of 5-HT receptor that binds the endogenous neurotransmitter serotonin. It is a G protein-coupled receptor (GPCR) that is coupled to Gi/Go and mediates inhibitory neurotransmission. HTR1A denotes the human gene encoding for the receptor.The HTR1A gene is located at 5q12.3. The decreases in 5-HT-1A receptor densities correlated with decreased glucose utilization as measured by PET scan. Activation of 5-HT-1A receptors has been demonstrated to impair cognition, leaing, and memory by inhibiting the release of glutamate and acetylcholine in various areas of the brain. 5-HT-1A receptors in the dorsal raphe nucleus are co-localized with neurokinin 1 (NK1) receptors and have been shown to inhibit the release of substance P, their endogenous ligand.
Clonality	Polyclonal
Cross Reactivity	No cross-reactivity with other proteins
Description	Boster Bio Anti-5HT1A Receptor/HTR1A Antibody catalog # PA1647. Tested in IHC, WB applications. This antibody reacts with Human, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Weste blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.
Function	G-protein coupled receptor for 5-hydroxytryptamine (serotonin). Also functions as a receptor for various drugs and psychoactive substances. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G prot
Host	Rabbit
Immunogen Region	A synthetic peptide corresponding to a sequence at the C-terminus of human 5HT1A Receptor, different from the related rat and mouse sequences by one amino acid.
Isotype	Rabbit IgG
Molecular Weight	46 kDa
Reactivity	Human, Rat
Reconstitution	Add 0.2ml of distilled water will yield a concentration of 500ug/ml.
Synonyms	5-hydroxytryptamine receptor 1A;5-HT-1A;5-HT1A;G-21;Serotonin receptor 1A;HTR1A;ADRB2RL1, ADRBRL1;
Tissue Specificity	Detected in lymph nodes, thymus and spleen. Detected in activated T-cells, but not in resting T-cells. .
Note	Each vial contains 4 mg Trehalose, 0.9 mg NaCl and 0.2 mg Na2HPO4.

Uniprot	P08908
Gene Name	HTR1A
Sequence	Belongs to the WD repeat BUB3 family.
Subcellular Location	Cell membrane ; Multi-pass membrane protein .

Conjugates	Biotin, Cy3, Dylight488, Dylight550, Dylight594, FITC, HRP, APC, PE, iFluor647, carrier-free

Concentration	Adding 0.2 ml of distilled water will yield a concentration of 500 ug/ml.
Form	Lyophilized
Purification	Immunogen affinity purified.
Storage	Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

Applications	IHC, WB
Description	Weste blot, 0.1-0.5ug/ml, Human, Rat<br> Immunohistochemistry (Paraffin-embedded Section), 2-5ug/ml, Human, Rat, By Heat<br>

Reference	1. Gilliam TC, Freimer NB, Kaufmann CA, Powchik PP, Bassett AS, Bengtsson U, Wasmuth JJ (November 1989). "Deletion Mapping of DNA Markers to a Region of Chromosome 5 That Cosegregates with Schizophrenia". Genomics 5 (4): 9404. <br /><br />2. Audero, E., Coppi, E., Mlinar, B., Rossetti, T., Caprioli, A., Banchaabouchi, M. A., Corradetti, R., Gross, C. Sporadic autonomic dysregulation and death associated with excessive serotonin autoinhibition.<br /><br />3. El Mestikawy, S., Fargin, A., Raymond, J. R., Gozlan, H., Hnatowich, M. The 5-HT(1A) receptor: an overview of recent advances. Neurochem. Res. 16: 1-10, 1991.<br /><br />

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Combination SKU	Supplier No.	Conjugation	Size	Your price	Quantity
BHA21006954-1	PA1647	-	100 ug	$370		Add to Cart
BHA21006954-2	PA1647-10ug	Sample	10 ug	$99		Add to Cart
BHA21006954-3	PA1647-Biotin	Biotin	100 ug	$570		Add to Cart
BHA21006954-4	PA1647-Cy3	Cy3	100 ug	$570		Add to Cart
BHA21006954-5	PA1647-Dylight488	Dylight488	100 ug	$570		Add to Cart
BHA21006954-6	PA1647-Dylight550	Dylight550	100 ug	$570		Add to Cart
BHA21006954-7	PA1647-Dylight594	Dylight594	100 ug	$570		Add to Cart
BHA21006954-8	PA1647-FITC	FITC	100 ug	$570		Add to Cart
BHA21006954-9	PA1647-HRP	HRP	100 ug	$570		Add to Cart
BHA21006954-10	PA1647-APC	APC	100 ug	$670		Add to Cart
BHA21006954-11	PA1647-PE	PE	100 ug	$670		Add to Cart
BHA21006954-12	PA1647-iFluor647	iFluor647	100 ug	$670		Add to Cart
BHA21006954-13	PA1647-carrier-free	carrier-free	100 ug	$370		Add to Cart

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