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Home / Primary Antibodies / Polyclonal Antibodies

Anti-53BP1/TP53BP1 Antibody Picoband®

SKU : BHA21004145

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Mfr.No.	A00397, A00397-10ug, A00397-Biotin, A00397-Cy3, A00397-Dylight488, A00397-Dylight550, A00397-Dylight594, A00397-FITC, A00397-HRP, A00397-APC, A00397-PE, A00397-iFluor647, A00397-carrier-free
Alternative Names	heterogeneous nuclear ribonucleoprotein A2/B1
Background	TP53BP1(Tumor Protein p53-Binding Protein 1), also called 53BP1, is a protein that in humans is encoded by the TP53BP1 gene. Iwabuchi et al.(1998) mapped the TP53BP1 gene to 15q15-q21 by FISH. Iwabuchi et al.(1994) showed that TP53BP1 binds to the conformationally sensitive central domain of wildtype p53 but not to mutant p53 in vitro. Immunoblot analysis by Iwabuchi et al.(1998) showed that expression of TP53BP1 or TP53BP2 enhances the transactivation function of p53 and induces the expression of p21(CDKN1A). Wang et al.(2002) used small interfering RNA ed against TP53BP1 in mammalian cells to demonstrate that TP53BP1 is a key transducer of the DNA damage checkpoint signal. TP53BP1 was required for p53 accumulation, G2/M checkpoint arrest, and the intra-S-phase checkpoint in response to ionizing radiation.
Clonality	Polyclonal
Cross Reactivity	No cross-reactivity with other proteins.
Description	Boster Bio Anti-53BP1/TP53BP1 Antibody Picoband® catalog # A00397. Tested in ELISA, Flow Cytometry, IF, IHC, ICC, WB applications. This antibody reacts with Human. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Weste blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.
Function	Heterogeneous nuclear ribonucleoprotein (hnRNP) that associates with nascent pre-mRNAs, packaging them into hnRNP particles. The hnRNP particle arrangement on nascent hnRNA is non- random and sequence-dependent and serves to condense and stabilize the tra
Host	Rabbit
Immunogen Region	E.coli-derived human 53BP1/TP53BP1 recombinant protein (Position: H1239-H1972).
Isotype	Rabbit IgG
Molecular Weight	450 kDa
Reactivity	Human
Reconstitution	Adding 0.2 ml of distilled water will yield a concentration of 500 ug/ml.
Synonyms	Heterogeneous nuclear ribonucleoproteins A2/B1; hnRNP A2/B1; HNRNPA2B1; HNRPA2B1
Tissue Specificity	Present in kidney, lung, testis and placenta, very low levels in liver.
Note	Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.

Uniprot	Q12888
Gene Id	7158
Gene Name	TP53BP1
Subcellular Location	Nucleus, nucleoplasm

Conjugates	Biotin, Cy3, Dylight488, Dylight550, Dylight594, FITC, HRP, APC, PE, iFluor647, carrier-free

Concentration	Adding 0.2 ml of distilled water will yield a concentration of 500 ug/ml.
Form	Lyophilized
Purification	Immunogen affinity purified.
Storage	At -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freezing and thawing.

Applications	ELISA, Flow Cytometry, IF, IHC, ICC, WB
Description	Weste blot, 0.25-0.5 ug/ml, Human<br> Immunohistochemistry(Paraffin-embedded Section), 2-5 ug/ml, Human<br> Immunocytochemistry/Immunofluorescence, 5 ug/ml, Human<br> Flow Cytometry (Fixed), 1-3 ug/1x10<sup>6</sup> cells, Human<br> ELISA, 0.1-0.5 ug/ml, -<br>

Reference	1. Iwabuchi, K., Bartel, P. L., Li, B., Marraccino, R., Fields, S. Two cellular proteins that bind to wild-type but not mutant p53. Proc. Nat. Acad. Sci. 91: 6098-6102, 1994. <br /><br />2. Iwabuchi, K., Li, B., Massa, H. F., Trask, B. J., Date, T., Fields, S. Stimulation of p53-mediated transcriptional activation by the p53-binding proteins, 53BP1 and 53BP2. J. Biol. Chem. 273: 26061-26068, 1998<br /><br />3. Wang, B., Matsuoka, S., Carpenter, P. B., Elledge, S. J. 53BP1, a mediator of the DNA damage checkpoint. Science 298: 1435-1438, 2002.

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Combination SKU	Supplier No.	Conjugation	Size	Your price	Quantity
BHA21004145-1	A00397	-	100 ug	$370		Add to Cart
BHA21004145-2	A00397-10ug	Sample	10 ug	$99		Add to Cart
BHA21004145-3	A00397-Biotin	Biotin	100 ug	$570		Add to Cart
BHA21004145-4	A00397-Cy3	Cy3	100 ug	$570		Add to Cart
BHA21004145-5	A00397-Dylight488	Dylight488	100 ug	$570		Add to Cart
BHA21004145-6	A00397-Dylight550	Dylight550	100 ug	$570		Add to Cart
BHA21004145-7	A00397-Dylight594	Dylight594	100 ug	$570		Add to Cart
BHA21004145-8	A00397-FITC	FITC	100 ug	$570		Add to Cart
BHA21004145-9	A00397-HRP	HRP	100 ug	$570		Add to Cart
BHA21004145-10	A00397-APC	APC	100 ug	$670		Add to Cart
BHA21004145-11	A00397-PE	PE	100 ug	$670		Add to Cart
BHA21004145-12	A00397-iFluor647	iFluor647	100 ug	$670		Add to Cart
BHA21004145-13	A00397-carrier-free	carrier-free	100 ug	$370		Add to Cart

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