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Home / Primary Antibodies / Polyclonal Antibodies

Anti-5 Lipoxygenase/ALOX5 Antibody Picoband®

SKU : BHA21006952

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Mfr.No.	PA1644, PA1644-10ug, PA1644-Biotin, PA1644-Cy3, PA1644-Dylight488, PA1644-Dylight550, PA1644-Dylight594, PA1644-FITC, PA1644-HRP, PA1644-APC, PA1644-PE, PA1644-iFluor647, PA1644-carrier-free
Alternative Names	Arachidonate 5-lipoxygenase
Background	ALOX5 (ARACHIDONATE 5-LIPOXYGENASE), also known as LOG5 or 5-LO (5-LIPOXYGENASE), is an enzyme that in humans is encoded by the ALOX5 gene. ALOX5 is a member of the lipoxygenase family of enzymes which also transforms EFAs into leukotrienes and is a current target for pharmaceutical intervention in a number of diseases. The enzyme 5-lipoxygenase catalyzes 2 reactions in the formation of leukotrienes. The ALOX5 gene is mapped to chromosome 10q11.21 based on an alignment of the ALOX5 sequence with the genomic sequence. Human 5-LO contains 3 nuclear localization sequences (NLSs) and a phosphorylation site involved in nuclear localization. Compared with age-matched 5-LO competent mice, the 5-LO knockout mice developed less right heart hypertrophy. Pharmacologic inhibition or ALOX5 gene disruption resulted in a significant decrease of beta-amyloid production and gamma-secretase levels. ALOX5 activity is short-lived, apparently in part because of an intrinsic instability of the enzyme.
Clonality	Polyclonal
Cross Reactivity	No cross-reactivity with other proteins
Description	Boster Bio Anti-5 Lipoxygenase/ALOX5 Antibody catalog # PA1644. Tested in IHC, WB applications. This antibody reacts with Human. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Weste blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.
Function	Catalyzes the first step in leukotriene biosynthesis, and thereby plays a role in inflammatory processes. .
Host	Rabbit
Immunogen Region	A synthetic peptide corresponding to a sequence at the C-terminus of human ALOX5, different from the related rat and mouse sequences by two amino acids.
Isotype	Rabbit IgG
Molecular Weight	78 kDa
Reactivity	Human
Reconstitution	Add 0.2ml of distilled water will yield a concentration of 500ug/ml.
Specificity	No cross reactivity with other proteins.
Synonyms	Arachidonate 5-lipoxygenase;5-LO;5-lipoxygenase;1.13.11.34;ALOX5;LOG5;
Note	Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3.

Uniprot	P09917
Gene Name	ALOX5
Sequence	Belongs to the lipoxygenase family.
Subcellular Location	Cytoplasm. Nucleus matrix. Nucleus membrane; Peripheral membrane protein. Shuttles between cytoplasm and nucleus. Found exclusively in the nucleus, when phosphorylated on Ser-272. Calcium binding promotes translocation from the cytosol and the nuclear matrix to the nuclear envelope and membrane association.

Conjugates	Biotin, Cy3, Dylight488, Dylight550, Dylight594, FITC, HRP, APC, PE, iFluor647, carrier-free

Concentration	Adding 0.2 ml of distilled water will yield a concentration of 500 ug/ml.
Form	Lyophilized
Purification	Immunogen affinity purified.
Storage	Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

Applications	IHC, WB
Description	Immunohistochemistry (Paraffin-embedded Section), 0.5-1ug/ml, Human, By Heat <br>Weste blot, 0.1-0.5ug/ml, Human<br>

Reference	1. Aliberti, J., Serhan, C., Sher, A. Parasite-induced lipoxin A4 is an endogenous regulator of IL-12 production and immunopathology in Toxoplasma gondii infection. J. Exp. Med. 196: 1253-1262, 2002.<br /><br />2. Bafica, A., Scanga, C. A., Serhan, C., Machado, F., White, S., Sher, A., Aliberti, J. Host control of Mycobacterium tuberculosis is regulated by 5-lipoxygenase-dependent lipoxin production. J. Clin. Invest. 115: 1601-1606, 2005.<br /><br />3. Funk CD, Hoshiko S, Matsumoto T, Rdmark O, Samuelsson B (April 1989). "Characterization of the human 5-lipoxygenase gene". Proc. Natl. Acad. Sci. U.S.A. 86 (8): 258791.<br /><br />

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Combination SKU	Supplier No.	Conjugation	Size	Your price	Quantity
BHA21006952-1	PA1644	-	100 ug	$370		Add to Cart
BHA21006952-2	PA1644-10ug	Sample	10 ug	$99		Add to Cart
BHA21006952-3	PA1644-Biotin	Biotin	100 ug	$570		Add to Cart
BHA21006952-4	PA1644-Cy3	Cy3	100 ug	$570		Add to Cart
BHA21006952-5	PA1644-Dylight488	Dylight488	100 ug	$570		Add to Cart
BHA21006952-6	PA1644-Dylight550	Dylight550	100 ug	$570		Add to Cart
BHA21006952-7	PA1644-Dylight594	Dylight594	100 ug	$570		Add to Cart
BHA21006952-8	PA1644-FITC	FITC	100 ug	$570		Add to Cart
BHA21006952-9	PA1644-HRP	HRP	100 ug	$570		Add to Cart
BHA21006952-10	PA1644-APC	APC	100 ug	$670		Add to Cart
BHA21006952-11	PA1644-PE	PE	100 ug	$670		Add to Cart
BHA21006952-12	PA1644-iFluor647	iFluor647	100 ug	$670		Add to Cart
BHA21006952-13	PA1644-carrier-free	carrier-free	100 ug	$370		Add to Cart

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