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Home / Primary Antibodies / Polyclonal Antibodies

Anti-3BP2/SH3BP2 Antibody Picoband®

SKU : BHA21005388

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Mfr.No.	A04008-1, A04008-1-10ug, A04008-1-Biotin, A04008-1-Cy3, A04008-1-Dylight488, A04008-1-Dylight550, A04008-1-Dylight594, A04008-1-FITC, A04008-1-HRP, A04008-1-APC, A04008-1-PE, A04008-1-iFluor647, A04008-1-carrier-free
Alternative Names	Ran-specific GTPase-activating protein
Background	SH3BP2 (SH3 domain-binding protein 2) is a protein that comes from a gene located on Chromosome 4. The protein encoded by this gene has an N-terminal pleckstrin homology (PH) domain, an SH3-binding proline-rich region, and a C-terminal SH2 domain. The protein binds to the SH3 domains of several proteins including the ABL1 and SYK protein tyrosine kinases , and functions as a cytoplasmic adaptor protein to positively regulate transcriptional activity in T, natural killer (NK), and basophilic cells. Mutations in this gene result in cherubism. Multiple transcript variants encoding different isoforms have been found for this gene.
Clonality	Polyclonal
Cross Reactivity	No cross-reactivity with other proteins.
Description	Boster Bio Anti-3BP2/SH3BP2 Antibody Picoband® catalog # A04008-1. Tested in ELISA, WB, Flow Cytometry applications. This antibody reacts with Human. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Weste blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.
Function	Inhibits GTP exchange on Ran. Forms a Ran-GTP-RANBP1 trimeric complex. Increase GTP hydrolysis induced by the Ran GTPase activating protein RANGAP1. May act in an intracellular signaling pathway which may control the progression through the cell cycle by
Host	Rabbit
Immunogen Region	E.coli-derived human 3BP2/SH3BP2 recombinant protein (Position: R256-R561).
Isotype	Rabbit IgG
Molecular Weight	70 kDa
Reactivity	Human
Reconstitution	Adding 0.2 ml of distilled water will yield a concentration of 500 ug/ml.
Synonyms	Ran-specific GTPase-activating protein;Ran-binding protein 1;RanBP1;RANBP1;
Tissue Specificity	Ubiquitously expressed. Present at highest levels in the brain, at high levels in the placenta and testis, at intermediate levels in the intestine, ovary, skeletal muscle and thymus and at lower levels in heart, kidney, liver, lung, pancreas, prostate and spleen. In the kidney, it is widely expressed in tubules, but sparsely expressed in the glomerulus (PubMed:24676636). Expression is significantly increased in renal biopsy specimens from idiopathic FSGS (PubMed:24676636). Overexpressed in many tumor types including breast, colorectal, endometrial, hepatic, kidney, lung, ovarian and pancreatic tumors.
Note	Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.

Uniprot	P78314
Gene Id	6452
Gene Name	SH3BP2
Subcellular Location	Cytoskeleton. Nucleus. Cell cortex. Bleb.

Conjugates	Biotin, Cy3, Dylight488, Dylight550, Dylight594, FITC, HRP, APC, PE, iFluor647, carrier-free

Concentration	Adding 0.2 ml of distilled water will yield a concentration of 500 ug/ml.
Form	Lyophilized
Purification	Immunogen affinity purified.
Storage	At -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months.Avoid repeated freezing and thawing.

Applications	ELISA, WB, Flow Cytometry
Description	Weste blot, 0.25-0.5 ug/ml, Human<br> Flow Cytometry (Fixed), 1-3 ug /1x10<sup>6</sup> cells, Human<br> ELISA, 0.1-0.5 ug/ml, -<br>

Reference	1. Bell, S. M., Shaw, M., Jou, Y.-S., Myers, R. M., Knowles, M. A. Identification and characterization of the human homologue of SH3BP2, an SH3 binding domain protein within a common region of deletion at 4p16.3 involved in bladder cancer. Genomics 44: 163-170, 1997.<br /><br />2. Lo, B., Faiyaz-Ul-Haque, M., Kennedy, S., Aviv, R., Tsui, L.-C., Teebi, A. S. Novel mutation in the gene encoding c-Abl-binding protein SH3BP2 causes cherubism. Am. J. Med. Genet. 121A: 37-40, 2003.<br /><br />3. Ueki, Y., Lin, C.-Y., Senoo, M., Ebihara, T., Agata, N., Onji, M., Saheki, Y., Kawai, T., Mukherjee, P. M., Reichenberger, E., Olsen, B. R. Increased myeloid cell responses to M-CSF and RANKL cause bone loss and inflammation in SH3BP2 'cherubism' mice. Cell 128: 71-83, 2007.

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Combination SKU	Supplier No.	Conjugation	Size	Your price	Quantity
BHA21005388-1	A04008-1	-	100 ug	$370		Add to Cart
BHA21005388-2	A04008-1-10ug	Sample	10 ug	$99		Add to Cart
BHA21005388-3	A04008-1-Biotin	Biotin	100 ug	$570		Add to Cart
BHA21005388-4	A04008-1-Cy3	Cy3	100 ug	$570		Add to Cart
BHA21005388-5	A04008-1-Dylight488	Dylight488	100 ug	$570		Add to Cart
BHA21005388-6	A04008-1-Dylight550	Dylight550	100 ug	$570		Add to Cart
BHA21005388-7	A04008-1-Dylight594	Dylight594	100 ug	$570		Add to Cart
BHA21005388-8	A04008-1-FITC	FITC	100 ug	$570		Add to Cart
BHA21005388-9	A04008-1-HRP	HRP	100 ug	$570		Add to Cart
BHA21005388-10	A04008-1-APC	APC	100 ug	$670		Add to Cart
BHA21005388-11	A04008-1-PE	PE	100 ug	$670		Add to Cart
BHA21005388-12	A04008-1-iFluor647	iFluor647	100 ug	$670		Add to Cart
BHA21005388-13	A04008-1-carrier-free	carrier-free	100 ug	$370		Add to Cart

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