Serine incorporator 3 / Axotomy-induced glycoprotein 1 is a protein that in humans is encoded by the SERINC3 gene. Also found on the membranes of the Golgi apparatus within cells, Axotomy-induced glycoprotein 1 is highly expressed in neuronal populations but is also found in thymus, kidney, liver and testis. Expression levels in tumors can be as much as tenfold the amount found in normal tissue of the same type. This increased expression implicates Axotomy-induced glycoprotein 1 as being involved in the cellular transformation from normal to malignant tissue. It is believed it contributes to oncogenesis by partially protecting cells from serum starvation and etoposide-induced apoptosis.
Formulation
0.5mg/ml if reconstituted with 0.2ml sterile DI water
Host
Rabbit
Immunogen Region
Recombinant mouse protein (amino acids E59-Y404) was used as the immunogen for the Aigp1 antibody.
Isotype
IgG
Predicted Reactivity
Mouse, Rat
Reactivity
Rat, Mouse
Recombinant
No
Subcellular Location
Cytoplasmic, cell membrane
Antigen
Aigp1
Uniprot
Q9QZI9
Buffer
Lyophilized from 1X PBS with 2% Trehalose
Format
Purified
Purification
Antigen affinity purified
Storage
After reconstitution, the Aigp1 antibody can be stored for up to one month at 4°C. For long-term, aliquot and store at -20°C. Avoid repeated freezing and thawing.
Applications
IF, FACS, WB, Direct ELISA
Dilution
Western blot: 0.5-1ug/ml,Immunofluorescence (FFPE): 5ug/ml,Flow cytometry: 1-3ug/million cells,Direct ELISA: 0.1-0.5ug/ml