A Disintegrin-Like and Metalloproteinase with Thrombospondin Type 1 Motif, 1, also known as METH1, is an enzyme that in humans is encoded by the ADAMTS1 gene. ADAMTS is a family of proteins believed to be anchored to the extracellular matrix(ECM) through interactions with aggregan or other matrix components by one or more thrombospondin type 1 motifs. Scott(2000) mapped the gene to 21q21.2 based on sequence similarity between the ADAMTS1 sequence and a chromosome 21q21.2 clone. Kuno et al.(1997) found that mouse Adamts1 expression could be induced in vitro in colon adenocarcinoma cells by stimulation with the inflammatory cytokine interleukin 1-alpha, or in vivo in kidney and heart by intravenous administration of lipopolysaccharide. Vazquez et al.(1999) determined that ADAMTS1 disrupts angiogenesis in vivo and in vitro more efficiently than ADAMTS8, THBS1, or endostatin.
Formulation
0.5mg/ml if reconstituted with 0.2ml sterile DI water
Host
Rabbit
Immunogen Region
Amino acids 956-968 (KHYIDFCTLTQCS-mouse) were used as the immunogen for this ADAMTS1 antibody.
Isotype
IgG
Predicted Reactivity
Mouse, Rat
Reactivity
Rat, Mouse
Recombinant
No
Antigen
ADAMTS1
Uniprot
P97857
Format
Antigen affinity purified
Purification
Antigen affinity
Storage
After reconstitution, the ADAMTS1 antibody can be stored for up to one month at 4°C. For long-term, aliquot and store at -20°C. Avoid repeated freezing and thawing.