AChR alpha, also called CHRNA, is mapped on 2q24-q32. This gene encodes the alpha subunit of the muscle acetylcholine receptor, which is the main target of pathogenic autoantibodies in autoimmune myasthenia gravis. The protein-coding sequence of the human alpha subunit gene is divided into 9 exons that correspond to different structural and functional domains of the precursor molecule.
Formulation
0.5mg/ml if reconstituted with 0.2ml sterile DI water
Host
Rabbit
Immunogen Region
Amino acids 22-36 (EHETRLVAKLFKDYS) from the alpha subunit were used as the immunogen for this nicotinic AChR antibody (100% homologous in human and rat).
Isotype
IgG
Predicted Reactivity
Human, Mouse, Rat
Reactivity
Human, Mouse, Rat
Recombinant
No
Antigen
AChR
Uniprot
P02708
Format
Antigen affinity purified
Purification
Antigen affinity
Storage
Store the lyophilized AChR antibody at 4°C. After reconstitution, aliquot and store at -20°C. Avoid repeated freezing and thawing.