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Home / Biochemicals / Small Molecules

PMA

SKU : BHB21300292

A PKC Activator

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Alomone Labs

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Mfr.No.	P-800, P-800_1 mg, P-800_10 mg, P-800_5 mg
Description	PMA (#P-800) is a highly pure, semi-synthetic, and biologically active compound.
Molecular Formula	C₃₆H₅₆O₈.
Synonyms	Semi-synthetic
Background	Phorbol 12-myristate 13-acetate (PMA) is the most commonly-used phorbol ester, primary found as extremely potent tumor promoter.1-3 PMA is a reversible activator of Protein Kinase C (PKC)4 in vivo and in vitro, even at nM concentrations (cells are usually treated with PMA at 200 nM to induce signaling). PMA promotes the expression of inducible NOS in cultured hepatocytes, activates Ca2+-ATPase pump and potentates forskolin-induced cAMP formation. In some cases PMA inhibits apoptosis induced by the Fas antigen, but induces apoptosis in HL-60 promyelocytic leukemia cells.5-8
Shipping	Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C
Concentration	200 nM.
Reconstitution	Centrifuge the vial before adding solvent (10,000 x g for 5 minutes) to spin down all the powder to the bottom of the vial. The lyophilized product may be difficult to visualize. Add solvent directly to the centrifuged vial. Tap the vial to aid in dissolving the lyophilized product. Tilt and gently roll the liquid over the walls of the vial. Avoid vigorous vortexing. Light vortexing for up to 3 seconds is acceptable if needed. The product is soluble in pure water at high micromolar concentrations (100 uM - 1 mM). For long-term storage in solution, we recommend preparing a stock solution by dissolving the product in double-distilled water (ddH2O) at a concentration between 100-1000x of the final working concentration. Divide the stock solution into small aliquots and store at -20°C. Before use, thaw the relevant vial(s) and dilute to the desired working concentration in your working buffer. Centrifuge all product preparations before use. It is recommended to prepare fresh solutions in working buffers just before use. Avoid multiple freeze-thaw cycles to maintain biological activity
Cas Number	16561-29-8
Molecular Weight	616.84
Solubility	DMSO or methanol. Centrifuge all product preparations before use (10000 x g 5 min).
Target	PKC
Activity	PMA is a commonly used phorbol ester and activates PKC in nM concentrations1. It has also been shown to be an extremely potent tumor promoter2-4.
Country Of Origin	Israel/IL
UNSPSC Code	41116134
Application	FC- Flow cytometry, IFC- Indirect flow cytometry, IHC- Immunohistochemistry,LCI- Live cell imaging, Calcium imaging assay,Cell survival assay, Electrophysiology, Neurite outgrowth assay
Lead Time	1-2 Business Days
Notes	Bioassay Tested: Yes Chemical Name: (1aR,1bS,4aR,7aS,7bS,8R,9R,9aS)-9a-(Acetyloxy)- 1a,1b,4, 4a,5,7a,7b,8,9,9a-decahydro-4a,7b-dihydroxy-3-(hydroxymethyl)-1,1,6,8-tetramethyl-5-oxo-1H-cyclopropa(3,4)benz (1,2-e)azulen-9-yl tetradecanoate.

Purity	>99.5%
Form	Lyophilized powder.
Storage	Storage After Reconstitution: The reconstituted solution can be stored at 4°C for up to 1 week. For longer periods (up to 6 months), small aliquots should be stored at -20°C. We do not recommend storing the product in working solutions for longer than a few days. Avoid multiple freeze-thaw cycles. Storage of solutions: Up to four weeks at 4°C or three months at -20°C.Highly irritable to skin and mucous membranes. Tumor promoter. Gloves and mask should be worn when using this product.

Product Manual	SDS

Reference	Janoff, A. et al. (1970) Cancer Res. 10, 2568. Weinstein, I.B. (1985) Carcinog. Compr. Surv. 10, 177. Isakov, N. et al. (1985) Biochem. Biophys. Res. Commun. 31, 724. Murray, A.W. and Froscio, M. (1977) Cancer Res. 37, 1360. Tepper, C.G. et al. (1995) Proc. Natl. Acad. Sci. USA 92, 8443. Oishi, K. et al. (1994) J. Cell. Biochem. 55, 168. Macfarlane, D.E. and O'Donnell, P.S. (1993) Leukemia 7, 1846. Hortelano, S. et al. (1992) J. Biol. Chem. 267, 24937. Murray, A.W. and Froscio, M. (1977) Cancer Res. 37, 1360. Janoff, A. et al. (1970) Cancer Res. 10, 2568. Weinstein, I.B. (1985) Carcinog. Compr. Surv. 10, 177. Isakov, N. et al. (1985) Biochem. Biophys. Res. Commun. 31, 724.

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Combination SKU	Supplier No.	Size	Your price	Quantity
BHB21300292-1	P-800_1 mg	1 mg	$103		Add to Cart
BHB21300292-2	P-800_10 mg	10 mg	$358		Add to Cart
BHB21300292-3	P-800_5 mg	5 mg	$211		Add to Cart
BHB21300292-4	P-800_1 mg	5x1 mg	$401		Add to Cart

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