MYB/CEP6 is a dual-color hybrid probe in which green dye directly labels the CEP6 probe, which specifically acts on chromosome 6 (D6Z1), while the red dye directly labels the MYB probe, which specifically acts on the probe. The MYB gene at the 6q23.2-23.3 region of the chromosomal region.
Description
hematological tumor
Clinical Significance
The 6q deletion abnormality is the fourth most common abnormality of B-CLL, about 10%, and the 6q deletion has a poor prognosis in various tumors including CLL; this probe can detect the small missing region of 2Mb which is not distinguishable by karyotype analysis.