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Home / Primary Antibodies / Monoclonal Antibodies

USP5 antibody

SKU : BHA10809322

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Mfr.No.	FNab09341
Alternative Names	Deubiquitinatingenzyme5 ; IsopeptidaseT ; ISOT ; Ubiquitinthiolesterase5 ; USP5
Background	Cleaves linear and branched multiubiquitin polymers with a marked preference for branched polymers. Involved in unanchored 'Lys-48'-linked polyubiquitin disassembly. Binds linear and 'Lys-63'-linked polyubiquitin with a lower affinity. Knock-down of USP5 causes the accumulation of p53/TP53 and an increase in p53/TP53 transcriptional activity because the unanchored polyubiquitin that accumulates is able to compete with ubiquitinated p53/TP53 but not with MDM2 for proteasomal recognition.
Categories	Primary Antibodies
Clonality	monoclonal
Description	Cleaves linear and branched multiubiquitin polymers with a marked preference for branched polymers. Involved in unanchored 'Lys-48'-linked polyubiquitin disassembly. Binds linear and 'Lys- 63'-linked polyubiquitin with a lower affinity. Knock-down of USP5 causes the accumulation of p53/TP53 and an increase in p53/TP53 transcriptional activity because the unanchored polyubiquitin that accumulates is able to compete with ubiquitinated p53/TP53 but not with MDM2 for proteasomal recognition.
Host	Mouse
Immunogen	ubiquitin specific peptidase 5(isopeptidase T)
Isotype	IgG1
Molecular Weight	93 kDa
Reactivity	Human
Regulatory	RUO
Synonyms	Deubiquitinating enzyme 5, Isopeptidase T, ISOT, Ubiquitin thiolesterase 5, USP5

Uniprot	P45974
Gene Id	8078
Clone No	6G1
Research Area	Epigenetics, Metabolism
Weight	93kDa

Form	liquid
Format	liquid
Purification	Protein A+G purification
Purity	>=95% as determined by SDS-PAGE
Storage	PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months(Avoid repeated freeze / thaw cycles.)

Applications

ELISA, WB

Description

ELISA ; WB

Dilution

WB	1:500-1:5000

Tested Application

WB: 1:500-1:5000

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SKU	Supplier No.	Size	Your price	Quantity
BHA10809322	FNab09341	100ug	$300		Add to Cart

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