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Home / Primary Antibodies / Monoclonal Antibodies

UBE3A Antibody / Ubiquitin-protein ligase E3A

SKU : BHA17110911

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NSJ Bioreagents

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Mfr.No.	RQ6275
Clonality	Monoclonal
Description	Ubiquitin-protein ligase E3A (UBE3A) also known as E6AP ubiquitin-protein ligase (E6AP) is an enzyme that in humans is encoded by the UBE3A gene. It is mapped to 15q11.2. This gene encodes an E3 ubiquitin-protein ligase, part of the ubiquitin protein degradation system. This imprinted gene is maternally expressed in brain and biallelically expressed in other tissues. Maternally inherited deletion of this gene causes Angelman Syndrome, characterized by severe motor and intellectual retardation, ataxia, hypotonia, epilepsy, absence of speech, and characteristic facies. The protein also interacts with the E6 protein of human papillomavirus types 16 and 18, resulting in ubiquitination and proteolysis of tumor protein p53. Alternative splicing of this gene results in three transcript variants encoding three isoforms with different N-termini. Additional transcript variants have been described, but their full length nature has not been determined.
Formulation	0.5mg/ml if reconstituted with 0.2ml sterile DI water
Host	Mouse
Immunogen Region	A human recombinant partial protein (amino acids M1-E860) was used as the immunogen for the UBE3A antibody.
Isotype	IgG2b
Predicted Reactivity	Human, Monkey
Reactivity	Human, Monkey
Recombinant	No

Antigen	Ubiquitin-protein ligase E3A
Uniprot	Q05086
Clone No	3F13

Format	Antigen affinity purified
Purification	Affinity purified
Storage	After reconstitution, the UBE3A antibody can be stored for up to one month at 4°C. For long-term, aliquot and store at -20°C. Avoid repeated freezing and thawing.

Applications	WB, FACS
Dilution	Western blot: 1-2ug/ml,Flow cytometry: 1-3ug/million cells

Product Manual	Data Sheet

No Description Available.

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SKU	Supplier No.	Size	Your price	Quantity
BHA17110911	RQ6275	100ug	$439		Add to Cart

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