Relays signals from the cell surface to the nucleus to weaken adherens junction and promote actin cytoskeleton reorganization and cell invasiveness. Involved in lysophosphatidic acid-induced cell adhesion and migration. Acts as a transcriptional coactivator for NF-kappa-B and JUN, and mediates the transrepression of these transcription factors induced by glucocorticoid receptor.
Categories
Primary Antibodies
Cellular Localization
Cell Junction, Cytoplasm, cytoskeleton, Nucleus
Clonality
monoclonal
Description
Relays signals from the cell surface to the nucleus to weaken adherens junction and promote actin cytoskeleton reorganization and cell invasiveness. Involved in lysophosphatidic acid-induced cell adhesion and migration. Acts as a transcriptional coactivator for NF-kappa-B and JUN, and mediates the transrepression of these transcription factors induced by glucocorticoid receptor.
Host
Mouse
Immunogen
thyroid hormone receptor interactor 6
Isotype
IgG1
Molecular Weight
50 kDa
Reactivity
Human, Mouse
Regulatory
RUO
Subcellular Location
Cell junction, Cytoplasm, Cytoskeleton, Nucleus
Synonyms
OIP 1, OIP1, Opa interacting protein 1, TR interacting protein 6, TRIP 6, TRIP6, ZRP 1, Zyxin related protein 1
Uniprot
Q15654
Gene Id
7205
Clone No
2G2
Research Area
Cell Division and Proliferation
Weight
50kDa
Form
liquid
Format
liquid
Purification
Protein A+G purification
Purity
>=95% as determined by SDS-PAGE
Storage
PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months(Avoid repeated freeze / thaw cycles.)