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Home / Primary Antibodies / Monoclonal Antibodies

TOP2A Antibody / Topoisomerase II alpha

SKU : BHA17110040

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NSJ Bioreagents

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Mfr.No.	RQ5364
Clonality	Monoclonal
Description	The TOP2A gene encodes a DNA topoisomerase, an enzyme that controls and alters the topologic states of DNA during transcription. This nuclear enzyme is involved in processes such as chromosome condensation, chromatid separation, and the relief of torsional stress that occurs during DNA transcription and replication. It catalyzes the transient breaking and rejoining of two strands of duplex DNA which allows the strands to pass through one another, thus altering the topology of DNA. Two forms of this enzyme exist as likely products of a gene duplication event. The gene encoding this form, alpha, is localized to chromosome 17 and the beta gene is localized to chromosome 3. The gene encoding this enzyme functions as the target for several anticancer agents and a variety of mutations in this gene have been associated with the development of drug resistance. Reduced activity of this enzyme may also play a role in ataxia-telangiectasia. (RefSeq)
Formulation	Antibody in PBS with 0.02% sodium azide and 50% glycerol
Host	Rabbit
Immunogen Region	A synthetic peptide specific to human Topoisomerase II alpha / TOP2A was used as the immunogen for the TOP2A antibody.
Isotype	IgG
Predicted Reactivity	Human, Mouse, Rat
Reactivity	Human, Mouse, Rat
Recombinant	No
Subcellular Location	Nuclear

Antigen	Topoisomerase II alpha
Uniprot	P11388
Clone No	FB-20

Format	Purified
Purification	Affinity purified
Storage	Store the TOP2A antibody at -20°C.

Applications	WB, IHC-P
Dilution	Western blot: 1:500-1:2000,Immunohistochemistry (FFPE): 1:50-1:200

Product Manual	Data Sheet

No Description Available.

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SKU	Supplier No.	Size	Your price	Quantity
BHA17110040	RQ5364	100ul	$439		Add to Cart

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