Toll-like Receptor 2 is a member of the Toll-like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. This protein is a cell-surface protein that can form heterodimers with other TLR family members to recognize conserved molecules derived from microorganisms known as pathogen-associated molecular patterns (PAMPs). Activation of TLRs by PAMPs leads to an up-regulation of signaling pathways to modulate the host's inflammatory response. This gene is also thought to promote apoptosis in response to bacterial lipoproteins. This gene has been implicated in the pathogenesis of several autoimmune diseases. (RefSeq)
Formulation
Antibody in PBS with 0.02% sodium azide and 50% glycerol
Host
Rabbit
Immunogen Region
A synthetic peptide specific to human TLR2 was used as the immunogen for the TLR2 antibody.
Isotype
IgG
Predicted Reactivity
Human
Reactivity
Human
Recombinant
No
Antigen
TLR2
Uniprot
O60603
Clone No
ADH-20
Format
Purified
Purification
Affinity purified
Storage
Store the TLR2 antibody at -20°C.
Applications
IHC-P, WB
Dilution
Western blot: 1:1000-1:2000, Immunohistochemistry (FFPE): 1:100-1:500