The protein encoded by the MAP3K7 gene is a member of the serine/threonine protein kinase family. This kinase mediates the signaling transduction induced by TGF beta and morphogenetic protein (BMP), and controls a variety of cell functions including transcription regulation and apoptosis. In response to IL-1, this protein forms a kinase complex including TRAF6, MAP3K7P1/TAB1 and MAP3K7P2/TAB2; this complex is required for the activation of nuclear factor kappa B. This kinase can also activate MAPK8/JNK, MAP2K4/MKK4, and thus plays a role in the cell response to environmental stresses.
Formulation
Antibody in PBS with 0.02% sodium azide and 50% glycerol
Host
Rabbit
Immunogen Region
A synthetic peptide specific to human MAP3K7/TAK1 was used as the immunogen for the TAK1 antibody.
Isotype
IgG
Predicted Reactivity
Human, Mouse
Reactivity
Human, Mouse
Recombinant
No
Antigen
TAK1
Uniprot
O43318
Clone No
ACHF-13
Format
Purified
Purification
Affinity purified
Storage
Store the TAK1 antibody at -20°C.
Applications
IF/ICC, WB
Dilution
Western blot: 1:500-1:2000,Immunofluorescence/Immunocytochemistry: 1:100-1:500