Spectrin, the predominant component of the membrane skeleton of the red cell, is essential in determining the properties of the membrane including its shape and deformability. It consists of 2 nonidentical subunits, alpha and beta. Spectrin is present in the red cell membrane in a tetrameric or possibly higher polymeric form through head-to-head self-association of heterodimers that are linked by actin polymers and protein 4.1 to form a 2-dimensional network. Non-erythroid spectrin gene is mapped to human chromosome 2. Spectrin mutations cause spinocerebellar ataxia type 5.
Formulation
0.5mg/ml with 1% BSA and 0.01% sodium azide if reconstituted with 0.2ml sterile 1XPBS
Host
Mouse
Immunogen Region
Human erythrocyte spectrin was used as the immunogen for this Spectrin antibody (alpha and beta).
Isotype
IgG1
Predicted Reactivity
Human
Reactivity
Human
Recombinant
No
Antigen
Spectrin
Gene Id
6708
Clone No
SB-SP1
Format
Ascites
Purification
Ascites
Storage
After reconstitution, the Spectrin antibody (alpha and beta) can be stored for up to one month at 4°C. For long-term, aliquot and store at -20°C. Avoid repeated freezing and thawing.