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Home / Primary Antibodies / Monoclonal Antibodies

Recombinant Cytochrome C Antibody

SKU : BHA17127146

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NSJ Bioreagents

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Mfr.No.	V8015SAF, V8015SAF-100UG
Clonality	Recombinant Rabbit Monoclonal
Description	In mammalian cells, the highly conserved cytochrome C protein is normally localized to the mitochondrial inter-membrane space. More recent studies have identified cytosolic cytochrome c as a factor necessary for activation of apoptosis. During apoptosis, cytochrome c is trans-located from the mitochondrial membrane to the cytosol, where it is required for activation of caspase-3 (CPP32). Overexpression of Bcl-2 has been shown to prevent the translocation of cytochrome c, thereby blocking the apoptotic process. Overexpression of Bax has been shown to induce the release of cytochrome c and to induce cell death. The release of cytochrome c from the mitochondria is thought to trigger an apoptotic cascade, whereby Apaf-1 binds to Apaf-3 (caspase-9) in a cytochrome c-dependent manner, leading to caspase-9 cleavage of caspase-3. This MAb recognizes total cytochrome C which includes both apocytochrome (i.e. cytochrome in the cytosol without heme attached) and holocytochrome (i.e. cytochrome in the mitochondria with heme attached).
Formulation	1 mg/ml in 1X PBS; BSA free, sodium azide free
Host	Rabbit
Immunogen Region	A recombinant full-length human protein was used as the immunogen for this recombinant Cytochrome C antibody.
Isotype	Rabbit IgG
Species Reactivity	Human, Mouse, Rat
Note	Optimal dilution of the antibody should be determined by the researcher.

Uniprot	P99999

Format	Purified
Purity	Protein A affinity chromatography
Storage	Store the recombinant Cytochrome C antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).

Applications	IHC-P, WB, FACS, IF
Description	Immunohistochemistry (FFPE): 0.25-0.5ug/ml,Flow cytometry: 1-2ug/million cells,Western blot: 1-2ug/ml,Immunofluorescence: 1-2ug/ml

Product Manual	<a href="https://www.nsjbio.com/tds-pdf/recombinant-cytochrome-c-antibody-cycs-3128r-v8015" target="_blank">Datasheet</a>

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SKU	Supplier No.	Size	Your price	Quantity
BHA17127146	V8015SAF, V8015SAF-100UG	100ug	$539		Add to Cart

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