The PNP gene encodes purine nucleoside phosphorylase, an enzyme that catalyzes the reversible phosphorolysis of the purine nucleosides and deoxynucleosides inosine, guanosine, deoxyinosine, and deoxyguanosine. It is presented results from gene dosage studies consistent with assignment of the PNP locus to band 14q13. PNP is expressed in most tissues, with markedly greater expression in lymphoid tissues. Genetic deficiencies of PNP result in severely compromised T?lymphocyte function and neurologic dysfunction.
Formulation
0.5mg/ml if reconstituted with 0.2ml sterile DI water
Host
Mouse
Immunogen Region
Amino acids AMSDAYDRTMRQRALSTWKQMGEQRELQE were used as the immunogen for the Purine nucleoside phosphorylase antibody.
Isotype
IgG2b
Predicted Reactivity
Rat, Human
Reactivity
Human, Rat
Recombinant
No
Subcellular Location
Cytoplasmic
Antigen
Purine nucleoside phosphorylase
Uniprot
P00491
Clone No
2H10
Buffer
Lyophilized from 1X PBS with 2% Trehalose
Format
Purified
Purification
Antigen affinity purified
Storage
After reconstitution, the Purine nucleoside phosphorylase antibody can be stored for up to one month at 4°C. For long-term, aliquot and store at -20°C. Avoid repeated freezing and thawing.