The protein encoded by the PIM1 gene belongs to the Ser/Thr protein kinase family, and PIM subfamily. This gene is expressed primarily in B-lymphoid and myeloid cell lines, and is overexpressed in hematopoietic malignancies and in prostate cancer. It plays a role in signal transduction in blood cells, contributing to both cell proliferation and survival, and thus provides a selective advantage in tumorigenesis. Both the human and orthologous mouse genes have been reported to encode two isoforms (with preferential cellular localization) resulting from the use of alternative in-frame translation initiation codons, the upstream non-AUG (CUG) and downstream AUG codons. (RefSeq)
Formulation
Antibody in PBS with 0.02% sodium azide and 50% glycerol
Host
Rabbit
Immunogen Region
A synthetic peptide specific to human PIM1 was used as the immunogen for the PIM1 antibody.
Isotype
IgG
Predicted Reactivity
Human, Mouse
Reactivity
Human, Mouse
Recombinant
No
Subcellular Location
Nuclear, cytoplasmic, cell membrane
Antigen
PIM1
Uniprot
P11309
Clone No
ECB-16
Format
Purified
Purification
Affinity purified
Storage
Store the PIM1 antibody at -20°C.
Applications
IHC-P, WB
Dilution
Western blot: 1:5000-1:10000,Immunohistochemistry (FFPE): 1:50-1:200