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Home / Primary Antibodies / Monoclonal Antibodies

p16

SKU : BHA15100429

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Mfr.No.	AMA08-5M
Clonality	Monoclonal
Description	p16, also known as cyclin-dependent kinase inhibitor 2A, CDKN2A or multiple tumor suppressor 1, plays an essential role in controlling the cell cycle. It functions by inhibiting the cyclin dependent kinase that phosphorylates another tumor suppressor protein called retinoblastoma protein which regulates the cell cycle. Due to its role in the cell cycle, mutations or deletions in the p16 gene has been implicated in many cancers. p16 has the potential to be a powerful tool in diagnosing and prognosing many gynecologic cancers. In some human papilloma virus (HPV) infections, the phosphorylated retinoblastoma protein is inactivated which in turn leads to the over expression of p16. This makes p16 a useful marker in evaluating HPV-associated squamous and glandular neoplasia of the lower gynecologic tract. There are other HPV independent mechanisms which lead to over expression of p16 such as ovarian serous carcinoma.
Host	Mouse
Isotype	IgG1
Reactivity	Human
Species	Mouse

Clone No	IHC116
Research Area	Infectious diseases, Immune system

Buffer	PBS
Concentration	1-3ug/ml
Storage	2-8°C

Applications	IHC

Product Manual	Datasheet SDS

No Description Available.

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Combination SKU	Supplier No.	Size	Your price	Quantity
AMA08-5M	AMA08-5M	6ml RTU	$387		Add to Cart
AMA08-10M	AMA08-10M	100 tests - i6000	$727		Add to Cart
AXA08-50D	AXA08-50D	50 tests - Xmatrx	$407		Add to Cart
AXA08-YCD	AXA08-YCD	160 tests - Xmatrx	$990		Add to Cart
MUA08-UC	MUA08-UC	1ml Conc	$795		Add to Cart
MUA08-5UC	MUA08-5UC	0.5ml Conc	$556		Add to Cart

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