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Home / Primary Antibodies / Monoclonal Antibodies

MSH6 Antibody

SKU : BHA17126460

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NSJ Bioreagents

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Mfr.No.	V7417SAF, V7417SAF-100UG
Clonality	Monoclonal (mouse origin)
Description	The finding that mutations in DNA mismatch repair genes are associated with hereditary nonpolyposis colorectal cancer (HNPCC) has resulted in considerable interest in the understanding of the mechanism of DNA mismatch repair. Initially, inherited mutations in the MSH2 and MLH1 homologs of the bacterial DNA mismatch repair genes mutS and mutL were demonstrated at high frequency in HNPCC and were shown to be associated with microsatellite instability. A member of the mismatch repair family, GTBP (also designated MSH6), is an MSH2-related protein that binds to DNA containing G/T mismatches. Findings suggest that the mismatch-binding factor in human cells is composed of a heterodimer of GTBP and MSH2.
Formulation	1 mg/ml in 1X PBS; BSA free, sodium azide free
Host	Mouse
Immunogen Region	A portion of amino acids 374-540 from the human protein were used as the immunogen for this MSH6 antibody.
Isotype	Mouse IgG2b, kappa
Species Reactivity	Human
Note	Optimal dilution of the MSH6 antibody should be determined by the researcher.1. The prediluted format is supplied in a dropper bottle and is optimized for use in IHC. After epitope retrieval step (if required), drip mAb solution onto the tissue section and incubate at RT for 30 min.

Uniprot	P52701

Format	Purified
Purity	Protein G affinity chromatography
Storage	Store the MSH6 antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).

Applications	ELISA, IF, WB, IHC-P
Description	ELISA: order BSA/sodium azide-free format for coating,Immunofluorescence: 1-2ug/ml,Western blot: 1-2ug/ml,Immunohistochemistry (FFPE): 1-2ug/ml for 30 min at RT

Product Manual	<a href="https://www.nsjbio.com/tds-pdf/msh6-antibody-msh6-3085-protein-microarray-validated-v7417" target="_blank">Datasheet</a>

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SKU	Supplier No.	Size	Your price	Quantity
BHA17126460	V7417SAF, V7417SAF-100UG	100ug	$539		Add to Cart

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