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Home / Primary Antibodies / Monoclonal Antibodies

Mouse Anti-Rat p75 NGF Receptor (extracellular) Antibody

SKU : BHA21300635

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Alomone Labs

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Mfr.No.	AN-170, AN-170_10 mcg, AN-170_100 mcg, AN-170_250 mcg, AN-170_50 mcg
Lead Time	1-2 Business Days
Immunogen Species	Rat
Background	p75NTR known as a cell surface receptor for NGF, BDNF, NT-3 and NT-4, is also a receptor for b-amyloid, and for the myelin axon repellant protein MAG.1,2,4,6 Binding of neurotrophins induces receptor dimerization followed by phosphorylation of receptor kinase residues and recruitment of intracellular proteins involved in signal transduction. p75NTR functions alone, or in functional complexes with the neurotrophin receptors trkA, trkB and trkC. p75NTR signals via interaction with different transducers such as TRAF6, IRAK, and RIP-2, activating NF-kappaB, JNK and p38, and inactivating rhoA.1,3,6 Receptor degradation is mediated by a metalloproteinase-dependent shedding of the extracellular domain. p75NTR binds all neurotrophins with similar nM affinity, but binds pro-neurotrophins with greater affinity, and is more potently activated by pro-neurotrophins.5Overexpression of the intracellular domain in developing neurons induces apoptosis. NGF-dependent association of NRIF with p75NTR contributes to pro-apoptotic signaling.7,8 Beta-amyloid peptide binds p75NTR and stimulates pro apoptotic signaling by p75NTR, suggesting that the receptor may be relevant for Alzheimer's disease.9
Clonality	Monoclonal
Description	Mouse Anti-Rat p75 NGF Receptor (extracellular) Antibody (#AN-170) is a highly specific monoclonal antibody directed against p75NTR. The antibody can be used in western blot, immunohistochemistry, and indirect flow cytometry applications. It has been designed to recognize p75NTR from rat samples only.
Formulation	PBS pH7.4, 1% BSA with 0.05% sodium azide
Host	Mouse
Isotype	IgG1
Reactivity	Rat
Reconstitution	10 ul, 50 ul, 100 ul or 250 ul double distilled water (DDW), depending on the sample size.
Shipping	Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C
Synonyms	p75NTR, NGFR p75, TNFR superfamily member 16, TNFRSF16, CD271
UNSPSC Code	41116161
Note	Homology: Recognizes p75NTR from rat samples only Peptide confirmation: Confirmed by amino acid analysis and mass spectrometry Specifictiy: NGFR AB Specifictiy: 192-IgG reacts with rat p75NTR. It does not cross-react with p75NTR of human or mouse origin. Is Toxin: No Standard quality control of each lot: Western blot analysis

Accession Number	Q08201
Gene Id	24596
Target	p75NTR, NGFR p75, TNFR superfamily member 16, TNFRSF16, CD271
Clone No	192-IgG
Sequence	Solubilized proteins from PC12 membranes.

Conjugates	Unconjugated

Concentration	1 mg/ml
Form	Lyophilized powder
Preservative	1% BSA, 0.05% NaN3
Purity	Affinity purified on immobilized antigen.
Storage	Storage After Reconstitution: The reconstituted solution can be stored at 4°C for up to 1 week. For longer periods, small aliquots should be stored at -20°C. Avoid multiple freezing and thawing. Centrifuge all antibody preparations before use (10000 x g 5 min). Storage Before Reconstitution: The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20°C

Applications	IF, IFC, IHC, WB
Dilution	1:400

Product Manual	SDS

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Combination SKU	Supplier No.	Size	Your price	Quantity
BHA21300635-1	AN-170_10 mcg	10 mcg	$377		Add to Cart
BHA21300635-2	AN-170_100 mcg	100 mcg	$697		Add to Cart
BHA21300635-3	AN-170_250 mcg	250 mcg	$977		Add to Cart
BHA21300635-4	AN-170_50 mcg	50 mcg	$797		Add to Cart

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