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Home / Primary Antibodies / Monoclonal Antibodies

Mouse Anti-Human Orai1 (extracellular) Antibody

SKU : BHA21300566

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Mfr.No.	ALM-025, ALM-025_100 mcg, ALM-025_25 mcg
Lead Time	1-2 Business Days
Immunogen Species	Human
Background	Cytosolic calcium (Ca2+) has long been known to act as a key second messenger in many intracellular pathways including synaptic transmission, muscle contraction, hormonal secretion, cell growth and proliferation.1,2 The mechanism controlling intracellular Ca2+ level influx either by the calcium-release-activated Ca2+ channels (CRAC), or from intracellular stores, has become of great interest.Recently, several key players of the store operated complex have been identified3. Orai1 (also known as CRACM1) acts as the store operated Ca2+ channel (SOC) and STIM1, which acts as the endoplasmic reticulum Ca2+ sensor3,4. The formation of functional channels requires the presence of both Orai1 and STIM1 proteins working as a complex and involves the co-clustering of Orai1 on the plasma membrane with STIM1 on the endoplasmic reticulum4-6. TRPC1, a member of the transient receptor potential family was also suggested to act as a player in the SOC complex7. In T-cells, Ca2+ entry following activation by antigen-receptor engagement occurs solely through CRAC channels where Orai1 constitutes the pore forming subunit3,8.Orai1 is a plasma membrane protein with four potential transmembrane domains and intracellular N- and C-terminus. In addition, two mammalian homologs to Orai1 have been identified; Orai2 and Orai33,9. All three, Orai1 Orai2 and Orai3, are capable of forming store operated channels with different magnitudes9.
Clonality	Monoclonal
Description	Mouse Anti-Human Orai1 (extracellular) Antibody (#ALM-025) is a highly specific monoclonal antibody directed against an extracellular epitope of the human Orai1 channel. The antibody can be used in western blot, immunocytochemical and indirect flow cytometry applications and was designed to recognize Orai1 from human samples only.
Formulation	PBS pH7.4, 1% BSA with 0.05% sodium azide
Host	Mouse
Immunogen Region	Extracellular
Isotype	IgM
Reactivity	Human
Reconstitution	25 ul or 100 ul double distilled water (DDW), depending on the sample size.
Shipping	Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C
Synonyms	TMEM142A, CRACM1, Calcium release-activated calcium channel protein 1
UNSPSC Code	41116161
Note	Homology: Orai1 from human samples only Peptide confirmation: Confirmed by amino acid analysis and mass spectrometry Specifictiy: ORAI1 AB Specifictiy: Recognizes only human Orai1. Is Toxin: No Standard quality control of each lot: Western blot analysis

Accession Number	Q96D31
Gene Id	84876
Target	TMEM142A, CRACM1, Calcium release-activated calcium channel protein 1
Clone No	3F11, D10, B9
Sequence	Synthetic peptide mapping to an extracellular sequence of human Orai1

Conjugates	Unconjugated

Concentration	1 mg/ml
Form	Lyophilized powder
Preservative	1% BSA, 0.05% NaN3
Purity	Affinity purified on immobilized antigen.
Storage	Storage After Reconstitution: The reconstituted solution can be stored at 4°C for up to 1 week. For longer periods, small aliquots should be stored at -20°C. Avoid multiple freezing and thawing. Centrifuge all antibody preparations before use (10000 x g 5 min). Storage Before Reconstitution: The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20°C

Applications	IC, IF, IFC, LCI, WB
Dilution	Contact Alomone for information

Product Manual	SDS

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Combination SKU	Supplier No.	Size	Your price	Quantity
BHA21300566-1	ALM-025_100 mcg	100 mcg	$1953		Add to Cart
BHA21300566-2	ALM-025_25 mcg	25 mcg	$697		Add to Cart

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