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Home / Primary Antibodies / Monoclonal Antibodies

Keratin 17 Antibody / Cytokeratin 17 / CK17

SKU : BHA17119348

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NSJ Bioreagents

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Mfr.No.	V8796, V8796-20UG, V8796-100UG
Clonality	Recombinant Rabbit Monoclonal
Description	Cytokeratin 17 (CK17) is normally expressed in the basal cells ofcomplex epithelia but not in stratified orsimple epithelia. Antibody to CK17 is an excellent tool to distinguish myoepithelial cells from luminal epithelium of various glandssuch as mammary, sweat and salivary. CK17 is expressed in epithelial cells of various origins, such as bronchial epithelial cells and skin appendages. It may be considered as epithelial stem cell marker because CK17 Ab marks basal cell differentiation. CK17 is expressed in SCLC much higher than in LADC. Eighty-five percent of the triple negative breast carcinomas immunoreact with basal cytokeratins including anti-CK17. Also important is that cases of triple negative breast carcinoma with expression of CK17 show an aggressive clinical course. Additionally, anti-CK17 and anti-MUC1 immunoreactivity represents pancreatobiliary subtype whereas anti-MUC2 and anti-CDX-2 positivity defines intestinal subtype.
Formulation	0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced), 0.05% sodium azide
Host	Rabbit
Immunogen Region	Recombinant full-length human KRT17 protein was used as the immunogen for the Keratin 17 antibody.
Isotype	Rabbit IgG
Species Reactivity	Human
Note	Optimal dilution of the Keratin 17 antibody should be determined by the researcher.

Uniprot	Q04695

Format	Purified
Purity	Protein A/G affinity
Storage	Aliquot the Keratin 17 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.

Applications	IHC-P
Description	Immunohistochemistry (FFPE): 1-2ug/ml

Product Manual	Datasheet

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