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Home / Primary Antibodies / Monoclonal Antibodies

IL33 antibody

SKU : BHA10804265

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Mfr.No.	FNab04272
Alternative Names	C9orf26 ; IL1F11 ; NFHEV
Background	Cytokine that binds to and signals through the IL1RL1/ST2 receptor which in tu activates NF-kappa-B and MAPK signaling pathways in target cells(PubMed:16286016). Involved in the maturation of Th2 cells inducing the secretion of T-helper type 2-associated cytokines. Also involved in activation of mast cells, basophils, eosinophils and natural killer cells. Acts as a chemoattractant for Th2 cells, and may function as an "alarmin", that amplifies immune responses during tissue injury(PubMed:17853410, PubMed:18836528). In quiescent endothelia the uncleaved form is constitutively and abundantly expressed, and acts as a chromatin-associated nuclear factor with transcriptional repressor properties, it may sequester nuclear NF-kappaB/RELA, lowering expression of its targets(PubMed:21734074). This form is rapidely lost upon angiogenic or proinflammatory activation(PubMed:18787100).
Categories	Primary Antibodies
Clonality	monoclonal
Description	Cytokine that binds to and signals through the IL1RL1/ST2 receptor which in tu activates NF-kappa-B and MAPK signaling pathways in target cells (PubMed:16286016). Involved in the maturation of Th2 cells inducing the secretion of T-helper type 2-associated cytokines. Also involved in activation of mast cells, basophils, eosinophils and natural killer cells. Acts as a chemoattractant for Th2 cells, and may function as an "alarmin", that amplifies immune responses during tissue injury (PubMed:17853410, PubMed:18836528). In quiescent endothelia the uncleaved form is constitutively and abundantly expressed, and acts as a chromatin- associated nuclear factor with transcriptional repressor properties, it may sequester nuclear NF-kappaB/RELA, lowering expression of its targets (PubMed:21734074). This form is rapidely lost upon angiogenic or proinflammatory activation (PubMed:18787100).
Host	Mouse
Immunogen	interleukin 33
Isotype	IgG1
Molecular Weight	35kd
Reactivity	Human
Regulatory	RUO
Synonyms	C9orf26, IL1F11, NFHEV

Uniprot	O95760
Gene Id	90865
Clone No	4E8
Research Area	Immunology, Cardiovascular

Form	liquid
Format	liquid
Purification	Protein A+G purification
Purity	>=95% as determined by SDS-PAGE
Storage	PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months(Avoid repeated freeze / thaw cycles.)

Applications	ELISA, WB
Description	ELISA ; WB
Tested Application	WB: 1:500-1:2000; IHC: 1:50-1:500

Manual	FNab04272.pdf

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SKU	Supplier No.	Size	Your price	Quantity
BHA10804265	FNab04272	100ug	$300		Add to Cart

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