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Home / Primary Antibodies / Monoclonal Antibodies

IDE Antibody / Insulin degrading enzyme

SKU : BHA17110097

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NSJ Bioreagents

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Mfr.No.	RQ5434
Clonality	Monoclonal
Description	The IDE gene encodes a zinc metallopeptidase that degrades intracellular insulin, and thereby terminates insulins activity, as well as participating in intercellular peptide signalling by degrading diverse peptides such as glucagon, amylin, bradykinin, and kallidin. The preferential affinity of this enzyme for insulin results in insulin-mediated inhibition of the degradation of other peptides such as beta-amyloid. Deficiencies in this protein's function are associated with Alzheimer's disease and type 2 diabetes mellitus but mutations in this gene have not been shown to be causitive for these diseases. This protein localizes primarily to the cytoplasm but in some cell types localizes to the extracellular space, cell membrane, peroxisome, and mitochondrion. Alternative splicing results in multiple transcript variants encoding distinct isoforms. (RefSeq)
Formulation	Antibody in PBS with 0.02% sodium azide and 50% glycerol
Host	Rabbit
Immunogen Region	A synthetic peptide specific to human Insulin-degrading enzyme / IDE was used as the immunogen for the IDE antibody.
Isotype	IgG
Predicted Reactivity	Human
Reactivity	Human
Recombinant	No

Antigen	IDE
Uniprot	P14735
Clone No	AOOB-9

Format	Purified
Purification	Affinity purified
Storage	Store the IDE antibody at -20°C.

Applications	WB
Dilution	Western blot: 1:500-1:2000

Product Manual	Data Sheet

No Description Available.

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SKU	Supplier No.	Size	Your price	Quantity
BHA17110097	RQ5434	100ul	$439		Add to Cart

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