This gene encodes the pro-alpha2 chain of type I collagen whose triple helix comprises two alpha1 chains and one alpha2 chain. Type I is a fibril-forming collagen found in most connective tissues and is abundant in bone, coea, dermis and tendon. Mutations in this gene are associated with osteogenesis imperfecta types I-IV, Ehlers-Danlos syndrome type VIIB, recessive Ehlers-Danlos syndrome Classical type, idiopathic osteoporosis, and atypical Marfan syndrome. Symptoms associated with mutations in this gene, however, tend to be less severe than mutations in the gene for the alpha1 chain of type I collagen (COL1A1) reflecting the different role of alpha2 chains in matrix integrity. Three transcripts, resulting from the use of alteate polyadenylation signals, have been identified for this gene.
Clonality
monoclonal
Host
Mouse
Immunogen
collagen, type I, alpha 2
Immunogen Region
collagen, type I, alpha 2
Isotype
IgG1
Reactivity
Human
Recommended Dilution
IHC: 1:2000 - 1:8000
Synonyms
Alpha 2 type I collagen, COL1A2, Collagen alpha 2(I) chain, Collagen Type I, collagen, type I, alpha 2, OI4
Uniprot
P08123
Gene Id
1278
Clone No
3D7
Research Area
Stem Cells, Cardiovascular
Form
liquid
Purification
protein A+G purified
Purity
>=95% as determined by SDS-PAGE
Storage
PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months (Avoid repeated freeze / thaw cycles.)
Tested Application
IHC: 1:200 - 1:1000
Product Manual
<a href="https://www.fn-test.com/content/uploads/product/manuals/antibody/FNab09910.pdf" target="_blank">Data Sheet</ a>