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Home / Primary Antibodies / Monoclonal Antibodies

Cleaved PARP Antibody

SKU : BHA17109976

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NSJ Bioreagents

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Mfr.No.	RQ5288
Clonality	Monoclonal
Description	The main role of PARP (found in the cell nucleus) is to detect and initiate an immediate cellular response to metabolic, chemical, or radiation-induced single-strand DNA breaks (SSB) by signaling the enzymatic machinery involved in the SSB repair. (Wiki) Cleavage of PARP, by enzymes such as caspases or cathepsins, typically inactivates PARP. While in vitro cleavage by caspase occurs throughout the caspase family, preliminary data suggest that caspase-3 and caspase-7 are responsible for in vivo cleavage. Cleavage occurs at aspartic acid 214 and glycine 215, separating PARP into a 24kDA and 89kDA segment. The smaller moiety includes the zinc finger motif requisite in DNA binding. The 89 kDa fragment includes the auto-modification domain and catalytic domain. (Wiki)
Formulation	Antibody in PBS with 0.02% sodium azide and 50% glycerol
Host	Rabbit
Immunogen Region	A synthetic peptide specific to human PARP (24kDa cleavage segment) was used as the immunogen for the Cleaved PARP antibody.
Isotype	IgG
Predicted Reactivity	Human, Mouse
Reactivity	Human, Mouse
Recombinant	No

Antigen	Cleaved PARP1
Uniprot	P09874
Clone No	HI-16

Format	Purified
Purification	Affinity purified
Storage	Store the Cleaved PARP antibody at -20°C.

Applications	IHC-P, WB
Dilution	Western blot: 1:500-1:2000,Immunohistochemistry (FFPE): 1:50-1:100

Product Manual	Data Sheet

No Description Available.

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SKU	Supplier No.	Size	Your price	Quantity
BHA17109976	RQ5288	100ul	$439		Add to Cart

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