After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane. The channel is blocked by alpha-bungarotoxin.
Categories
Primary Antibodies
Clonality
monoclonal
Description
After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane. The channel is blocked by alpha-bungarotoxin.
Host
Mouse
Immunogen
cholinergic receptor, nicotinic, alpha 7
Isotype
IgG2a
Molecular Weight
56 kDa
Reactivity
Human
Regulatory
RUO
Synonyms
CHRNA7, CHRNA7 2, NACHRA7
Uniprot
P36544
Gene Id
89832
Clone No
4B8
Research Area
Signal Transduction, Neuroscience
Form
liquid
Format
liquid
Purification
Protein A+G purification
Purity
>=95% as determined by SDS-PAGE
Storage
PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months(Avoid repeated freeze / thaw cycles.)