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Home / Primary Antibodies / Monoclonal Antibodies

CDC6 Antibody

SKU : BHA17103835

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NSJ Bioreagents

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Mfr.No.	R30018
Clonality	Monoclonal
Description	In yeasts, Cdc6(Saccharomyces cerevisiae) and Cdc18(Schizosaccharomyces pombe) associate with the origin recognition complex(ORC) proteins to render cells competent for DNA replication. Cdc6 is overexpressed in human cancers, where it has a critical regulatory role in addition to DNA replication. Yan et al.(1998) showed that Cdc6 is expressed selectively in proliferating but not quiescent mammalian cells, both in culture and within tissues in intact animals. During the transition from a growth-arrested to a proliferative state, transcription of mammalian Cdc6 is regulated by E2F proteins, as revealed by a functional analysis of the human Cdc6 promoter and by the ability of exogenously expressed E2F proteins to stimulate the endogenous Cdc6 gene. They conclude that expression of human Cdc6 is regulated in response to mitogenic signals though transcriptional control mechanisms involving E2F proteins, and that Cdc6 is required for initiation of DNA replication in mammalian cells.
Formulation	0.5mg/ml with 1% BSA and 0.01% sodium azide if reconstituted with 0.2ml sterile 1XPBS
Host	Mouse
Immunogen Region	Recombinant human protein was used as the immunogen for this CDC6 antibody.
Isotype	IgG1
Predicted Reactivity	Human
Reactivity	Human
Recombinant	No

Antigen	CDC6
Gene Id	990
Clone No	IMD-6

Format	Ascites
Purification	Ascites
Storage	After reconstitution, the CDC6 antibody can be stored for up to one month at 4°C. For long-term, aliquot and store at -20°C. Avoid repeated freezing and thawing.

Applications	WB
Dilution	Western blot: 1-2ug/ml

Product Manual	Data Sheet

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SKU	Supplier No.	Size	Your price	Quantity
BHA17103835	R30018	100ug	$439		Add to Cart

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