CD4 Biotin SK3 IgG1,k (RUO)

Mfr.No.	112050, 112051, 112055
Clonality	Monoclonal
Description	The clone SK3, a mouse monoclonal antibody selectively binds with a 55-59kD type I transmembrane glycoprotein and a member of the immunoglobulin superfamily. CD4 contains four extracellular Ig-like domains (D1-D4). The epitope for SK3 is located within the D3 domain of the protein, which has a structure resembling an Ig variable domain. Expression of CD4 is observed in subsets of T lymphocytes, monocytes, macrophages, and dendritic cells. Through interaction of MHC-II, CD4 facilitates cell-cell interaction, thymic differentiation, and activation of downstream signaling cascades. HIV infection of T-cells is instigated through binding of HIV to CD4. Binding of SK3 antibody blocks HIV infection through CD4 and also blocks the mixed lymphocyte reaction (MLR).
Host	Mouse
Immunogen Region	Human peripheral blood T cells
Isotype	IgG1,k
Reactivity	Cynomolgus monkey, Human, Rhesus

Product Manual	Datasheet MSDS

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Combination SKU	Supplier No.	Size	Your price
BHA19900409-1	112050	50 ug	$95	Add to Cart
BHA19900409-2	112051	100 ug	$170	Add to Cart
BHA19900409-3	112055	500 ug	$595	Add to Cart