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Home / Primary Antibodies / Monoclonal Antibodies

CD22 antibody

SKU : BHA10801439

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Mfr.No.	FNab01444
Alternative Names	SIGLEC2
Background	Mediates B-cell B-cell interactions. May be involved in the localization of B-cells in lymphoid tissues. Binds sialylated glycoproteins; one of which is CD45. Preferentially binds to alpha-2,6-linked sialic acid. The sialic acid recognition site can be masked by cis interactions with sialic acids on the same cell surface. Upon ligand induced tyrosine phosphorylation in the immune response seems to be involved in regulation of B-cell antigen receptor signaling. Plays a role in positive regulation through interaction with Src family tyrosine kinases and may also act as an inhibitory receptor by recruiting cytoplasmic phosphatases via their SH2 domains that block signal transduction through dephosphorylation of signaling molecules.
Categories	Primary Antibodies
Clonality	monoclonal
Description	Mediates B-cell B-cell interactions. May be involved in the localization of B-cells in lymphoid tissues. Binds sialylated glycoproteins; one of which is CD45. Preferentially binds to alpha-2,6-linked sialic acid. The sialic acid recognition site can be masked by cis interactions with sialic acids on the same cell surface. Upon ligand induced tyrosine phosphorylation in the immune response seems to be involved in regulation of B-cell antigen receptor signaling. Plays a role in positive regulation through interaction with Src family tyrosine kinases and may also act as an inhibitory receptor by recruiting cytoplasmic phosphatases via their SH2 domains that block signal transduction through dephosphorylation of signaling molecules.
Host	Mouse
Immunogen	CD22 molecule
Isotype	IgG1
Molecular Weight	135 kDa
Reactivity	Human
Regulatory	RUO
Synonyms	B cell receptor CD22, BL CAM, CD22, CD22 molecule, SIGLEC 2, SIGLEC2, T cell surface antigen Leu 14

Uniprot	P20273
Gene Id	933
Clone No	7D10
Research Area	Stem Cells, Immunology, Signal Transduction, Cancer

Form	liquid
Format	liquid
Purification	Protein A+G purification
Purity	>=95% as determined by SDS-PAGE
Storage	PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months(Avoid repeated freeze / thaw cycles.)

Applications	ELISA, WB, IHC
Description	ELISA ; WB ; IHC
Tested Application	WB : 1:1000-1:10000 IHC : 1:200-1:800

Manual	FNab01444.pdf

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SKU	Supplier No.	Size	Your price	Quantity
BHA10801439	FNab01444	100ug	$260		Add to Cart

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