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Home / Primary Antibodies / Monoclonal Antibodies

CD137

SKU : BHA15100451

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BioGenex Laboratories

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Mfr.No.	AMB03-5M
Clonality	Monoclonal
Description	CD137, also known as TNFRSF9 or 4-1BB, is a member of the tumor necrosis factor receptor superfamily, represents a promising target for enhancing antitumor immune responses. It is an inducible costimulatory molecule expressed mainly on activated T cells. The functions of CD137 in T lymphocytes include regulating activation, proliferation and apoptosis. The ligand for CD137, known as 4-1BBL, is expressed on activated macrophages, mature B cells, hematopoietic stem cells, and myeloid progenitor cells. CD137 helps regulate the activation of many immune cells, including CD4 (+) T cells, CD8 (+) T cells, dendritic cells, and natural killer cells. CD137 signaling leads to maintaining the survival of activated T cells and CD8+ memory T cells, and clonal expansion of T cells, but also to suppressing myelopoiesis and Dendritic cell development. Triggered CD137 induces a cytokine release profile regulating peripheral monocytes survival. Recent studies indicate that the antitumor efficacy of therapeutic tumor-targeting antibodies can be augmented by the addition of agonistic antibodies targeting CD137. As ligation of CD137 provides a costimulatory signal in multiple immune cell subsets, CD137 antibody has potential to improve cancer treatment, and has been implicated in breast cancer, melanoma and lymphoma. Therefore, CD137 agonists represent a promising immunotherapeutic approach to treating cancers.
Host	Mouse
Isotype	IgG1
Reactivity	Human
Species	Mouse

Clone No	BBK-2
Research Area	Infectious diseases, Immune system

Buffer	PBS
Concentration	1-3ug/ml
Storage	2-8°C

Applications	IHC
Dilution	1:20-50

Product Manual	Datasheet SDS

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Combination SKU	Supplier No.	Size	Your price	Quantity
AMB03-5M	AMB03-5M	6 mL	$280		Add to Cart
AMB03-10M	AMB03-10M	100 tests - i6000	$523		Add to Cart
AXB03-50D	AXB03-50D	50 tests - Xmatrx	$294		Add to Cart
AXB03-YCD	AXB03-YCD	160 tests - Xmatrx	$718		Add to Cart
MUB03-UC	MUB03-UC	1ml Conc	$574		Add to Cart
MUB03-5UC	MUB03-5UC	0.5ml Conc	$404		Add to Cart

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