Cathepsin L is a lysosomal cysteine proteinase with a major role in intracellular protein catabolism. It also shows the most potent collagenolytic and elastinolytic activity in vitro of any of the cathepsins. Cathepsin L has been implicated in pathologic processes including myofibril necrosis in myopathies and in myocardial ischemia, and in the renal tubular response to proteinuria. Human liver cathepsin L consists of a heavy chain of about 25 kD and a light chain of about 5 kD. The gene is mapped to 9q21-q22. Cathepsin L is required for endothelial progenitor cell-induced neovascularization.
Formulation
0.5mg/ml with 1% BSA and 0.01% sodium azide if reconstituted with 0.2ml sterile 1XPBS
Host
Mouse
Immunogen Region
Procathepsin L isolated from the human lung cancer cell line EPLC 32M1 was used as the immunogen for this Cathepsin L antibody.
Isotype
IgG1
Predicted Reactivity
Human, mouse, rat
Reactivity
mouse, rat, Human
Recombinant
No
Antigen
Cathepsin L
Gene Id
1514
Clone No
CP-L14
Format
Ascites
Purification
Ascites
Storage
After reconstitution, the Cathepsin L antibody can be stored for up to one month at 4°C. For long-term, aliquot and store at -20°C. Avoid repeated freezing and thawing.
Applications
IHC-F, WB
Dilution
Western blot: 2ug/ml,Immunohistochemistry (Frozen): 4ug/ml-formalin/acetone fixed tissues