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Home / Primary Antibodies / Monoclonal Antibodies

Anti-ZAP70 Antibody Picoband® (monoclonal, 9D5)

SKU : BHA21002604

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Mfr.No.	M00754-5, M00754-5-10ug, M00754-5-Biotin, M00754-5-Cy3, M00754-5-Dylight488, M00754-5-Dylight550, M00754-5-Dylight594, M00754-5-FITC, M00754-5-HRP, M00754-5-APC, M00754-5-PE, M00754-5-iFluor647, M00754-5-carrier-free
Alternative Names	zeta chain of T cell receptor associated protein kinase 70kDa
Background	ZAP-70 (Zeta-chain-associated protein kinase 70) encodes an enzyme belonging to the protein tyrosine kinase family, and it plays a role in T-cell development and lymphocyte activation. This enzyme, which is phosphorylated on tyrosine residues upon T-cell antigen receptor (TCR) stimulation, functions in the initial step of TCR-mediated signal transduction in combination with the Src family kinases, Lck and Fyn. This enzyme is also essential for thymocyte development. Mutations in this gene cause selective T-cell defect, a severe combined immunodeficiency disease characterized by a selective absence of CD8-positive T-cells. Two transcript variants that encode different isoforms have been found for this gene.
Clonality	Monoclonal
Cross Reactivity	No cross-reactivity with other proteins.
Description	Boster Bio Anti-ZAP70 Antibody Picoband® (monoclonal, 9D5) catalog # M00754-5. Tested in Flow Cytometry, WB applications. This antibody reacts with Human, Mouse, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Weste blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.
Function	Tyrosine kinase that plays an essential role in regulation of the adaptive immune response. Regulates motility, adhesion and cytokine expression of mature T-cells, as well as thymocyte development. Contributes also to the development and activation of pri
Host	Mouse
Immunogen Region	A synthetic peptide corresponding to a sequence in the middle region of human ZAP70, different from the related mouse sequence by two amino acids.
Isotype	Mouse IgG2b
Molecular Weight	72 kDa
Reactivity	Human, Mouse, Rat
Reconstitution	Add 0.2ml of distilled water will yield a concentration of 500ug/ml.
Specificity	No cross reactivity with other proteins.
Synonyms	SRK; STD; TZK; ZAP70; ZAP-70; ZAP 70; P43403
Tissue Specificity	Expressed in T- and natural killer cells. Also present in early thymocytes and pro/pre B-cells.
Note	Each vial contains 4mg Trehalose, 0.9mg NaCl, 0.2mg Na<sub>2</sub>HPO<sub>4</sub>, 0.05mg NaN<sub>3</sub>.

Uniprot	P43403
Gene Id	7535
Gene Name	ZAP70
Clone No	Clone: 9D5
Subcellular Location	Cell membrane. Cytoplasm. Membrane.

Conjugates	Biotin, Cy3, Dylight488, Dylight550, Dylight594, FITC, HRP, APC, PE, iFluor647, carrier-free

Concentration	Adding 0.2 ml of distilled water will yield a concentration of 500 ug/ml.
Form	Lyophilized
Purification	Immunogen affinity purified.
Storage	Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

Applications	WB, Flow Cytometry
Description	Weste blot, 0.1-0.5ug/ml, Human, Mouse, Rat<br> Flow Cytometry (Fixed), 1-3ug/1x10<sup>6</sup> cells, Human<br>

Reference	1. Lupher ML, Reedquist KA, Miyake S, Langdon WY, Band H (Sep 1996). "A novel phosphotyrosine-binding domain in the N-terminal transforming region of Cbl interacts ly and selectively with ZAP-70 in T cells".The Joual of Biological Chemistry 271 (39): 240638.<br /><br />2. Meng W, Sawasdikosol S, Burakoff SJ, Eck MJ (Mar 1999). "Structure of the amino-terminal domain of Cbl complexed to its binding site on ZAP-70 kinase". Nature 398 (6722): 8490.<br /><br />3. Neumeister EN, Zhu Y, Richard S, Terhorst C, Chan AC, Shaw AS (Jun 1995). "Binding of ZAP-70 to phosphorylated T-cell receptor zeta and eta enhances its autophosphorylation and generates specific binding sites for SH2 domain-containing proteins". Molecular and Cellular Biology 15 (6): 31718.<br /><br />

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Combination SKU	Supplier No.	Conjugation	Size	Your price	Quantity
BHA21002604-1	M00754-5	-	100 ug	$370		Add to Cart
BHA21002604-2	M00754-5-10ug	Sample	10 ug	$99		Add to Cart
BHA21002604-3	M00754-5-Biotin	Biotin	100 ug	$570		Add to Cart
BHA21002604-4	M00754-5-Cy3	Cy3	100 ug	$570		Add to Cart
BHA21002604-5	M00754-5-Dylight488	Dylight488	100 ug	$570		Add to Cart
BHA21002604-6	M00754-5-Dylight550	Dylight550	100 ug	$570		Add to Cart
BHA21002604-7	M00754-5-Dylight594	Dylight594	100 ug	$570		Add to Cart
BHA21002604-8	M00754-5-FITC	FITC	100 ug	$570		Add to Cart
BHA21002604-9	M00754-5-HRP	HRP	100 ug	$570		Add to Cart
BHA21002604-10	M00754-5-APC	APC	100 ug	$670		Add to Cart
BHA21002604-11	M00754-5-PE	PE	100 ug	$670		Add to Cart
BHA21002604-12	M00754-5-iFluor647	iFluor647	100 ug	$670		Add to Cart
BHA21002604-13	M00754-5-carrier-free	carrier-free	100 ug	$370		Add to Cart

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