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Home / Primary Antibodies / Monoclonal Antibodies

Anti-SNRPN Antibody Picoband® (monoclonal, 6F12)

SKU : BHA21002125

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Mfr.No.	M02173, M02173-10ug, M02173-Biotin, M02173-Cy3, M02173-Dylight488, M02173-Dylight550, M02173-Dylight594, M02173-FITC, M02173-HRP, M02173-APC, M02173-PE, M02173-iFluor647, M02173-carrier-free
Alternative Names	small nuclear ribonucleoprotein polypeptide N
Background	SNRPN (Small Nuclear Ribonucleoprotein Polypeptide N), also called SMN, is a bicistronic imprinted gene that encodes 2 polypeptides, the SmN splicing factor, which is involved in RNA processing, and the SNRPN upstream reading frame (SNURF) polypeptide. The protein encoded by this gene is one polypeptide of a small nuclear ribonucleoprotein complex and belongs to the snRNP SMB/SMN family. SNRPN also encodes a long alteatively spliced transcript containing several small nucleolar RNAs (snoRNAs) and extends downstream to partially overlap the UBE3A gene in the antisense orientation. PWS arises from loss of function of genes in this region expressed exclusively from the pateal chromosome, suggesting that SNRPN may play a role in its etiology. The SNRPN gene is mapped on 15q11.2. Analysis of mateal DNA and of SNRPN cDNA confirmed that the mateal allele is not expressed in fetal brain and heart. Deletions in the transcription unit of the imprinted SNRPN gene occur in patients who have PWS or Angelman syndrome because of a parental imprint switch failure in this chromosomal domain.
Clonality	Monoclonal
Cross Reactivity	No cross-reactivity with other proteins.
Description	Boster Bio Anti-SNRPN Antibody Picoband® (monoclonal, 6F12) catalog # M02173. Tested in Flow Cytometry, WB applications. This antibody reacts with Human, Mouse, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Weste blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.
Function	May be involved in tissue-specific alteative RNA processing events.
Host	Mouse
Immunogen Region	A synthetic peptide corresponding to a sequence at the N-terminus of human SNRPN, identical to the related mouse and rat sequences.
Isotype	Mouse IgG2b
Molecular Weight	26 kDa
Reactivity	Human, Mouse, Rat
Reconstitution	Add 0.2ml of distilled water will yield a concentration of 500ug/ml.
Specificity	No cross reactivity with other proteins.
Synonyms	Small nuclear ribonucleoprotein-associated protein N; snRNP-N; Sm protein D; Sm-D; Sm protein N; Sm-N; SmN; Tissue-specific-splicing protein; SNRPN; HCERN3; SMN
Tissue Specificity	Expressed in brain and lymphoblasts.
Note	Each vial contains 4mg Trehalose, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg NaN3.

Uniprot	P63162
Gene Id	6638
Gene Name	SNRPN
Clone No	Clone: 6F12
Subcellular Location	Nucleus.

Conjugates	Biotin, Cy3, Dylight488, Dylight550, Dylight594, FITC, HRP, APC, PE, iFluor647, carrier-free

Concentration	Adding 0.2 ml of distilled water will yield a concentration of 500 ug/ml.
Form	Lyophilized
Purification	Immunogen affinity purified.
Storage	Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

Applications	Flow Cytometry, WB
Description	Weste blot, 0.1-0.5ug/ml<br> Flow Cytometry (Fixed), 1-3ug/1x10<sup>6</sup> cells<br>

Reference	1.Bielinska, B., Blaydes, S. M., Buiting, K., Yang, T., Krajewska-Walasek, M., Horsthemke, B., Brannan, C. I. De novo deletions of SNRPN exon 1 in early human and mouse embryos result in a pateal to mateal imprint switch. Nature Genet. 25: 74-78, 2000.<br /><br />2.Cattanach, B. M., Barr, J. A., Evans, E. P., Burtenshaw, M., Beechey, C. V., Leff, S. E., Brannan, C. I., Copeland, N. G., Jenkins, N. A., Jones, J. A candidate mouse model for Prader-Willi syndrome which shows an absence of Snrpn expression. Nature Genet. 2: 270-274, 1992.<br /><br />3.Geuns, E., De Rycke, M., Van Steirteghem, A., Liebaers, I. Methylation imprints of the imprint control region of the SNRPN-gene in human gametes and preimplantation embryos. Hum. Molec. Genet. 12: 2873-2879, 2003.

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Combination SKU	Supplier No.	Conjugation	Size	Your price	Quantity
BHA21002125-1	M02173	-	100 ug	$370		Add to Cart
BHA21002125-2	M02173-10ug	Sample	10 ug	$99		Add to Cart
BHA21002125-3	M02173-Biotin	Biotin	100 ug	$570		Add to Cart
BHA21002125-4	M02173-Cy3	Cy3	100 ug	$570		Add to Cart
BHA21002125-5	M02173-Dylight488	Dylight488	100 ug	$570		Add to Cart
BHA21002125-6	M02173-Dylight550	Dylight550	100 ug	$570		Add to Cart
BHA21002125-7	M02173-Dylight594	Dylight594	100 ug	$570		Add to Cart
BHA21002125-8	M02173-FITC	FITC	100 ug	$570		Add to Cart
BHA21002125-9	M02173-HRP	HRP	100 ug	$570		Add to Cart
BHA21002125-10	M02173-APC	APC	100 ug	$670		Add to Cart
BHA21002125-11	M02173-PE	PE	100 ug	$670		Add to Cart
BHA21002125-12	M02173-iFluor647	iFluor647	100 ug	$670		Add to Cart
BHA21002125-13	M02173-carrier-free	carrier-free	100 ug	$370		Add to Cart

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