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Home / Primary Antibodies / Monoclonal Antibodies

Anti-SAE2/UBA2 Antibody Picoband® (monoclonal, 5B13)

SKU : BHA21002390

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Mfr.No.	M03816-2, M03816-2-10ug, M03816-2-Biotin, M03816-2-Cy3, M03816-2-Dylight488, M03816-2-Dylight550, M03816-2-Dylight594, M03816-2-FITC, M03816-2-HRP, M03816-2-APC, M03816-2-PE, M03816-2-iFluor647, M03816-2-carrier-free
Alternative Names	ubiquitin like modifier activating enzyme 2
Background	Ubiquitin-like 1-activating enzyme E1B (UBLE1B) also known as SUMO-activating enzyme subunit 2 (SAE2) is an enzyme that in humans is encoded by the UBA2 gene. Posttranslational modification of proteins by the addition of the small protein SUMO (see SUMO1; MIM 601912), or sumoylation, regulates protein structure and intracellular localization. SAE1 (MIM 613294) and UBA2 form a heterodimer that functions as a SUMO-activating enzyme for the sumoylation of proteins
Clonality	Monoclonal
Cross Reactivity	No cross-reactivity with other proteins.
Description	Boster Bio Anti-SAE2/UBA2 Antibody Picoband® (monoclonal, 5B13) catalog # M03816-2. Tested in IHC, WB applications. This antibody reacts with Human, Mouse, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Weste blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.
Function	The heterodimer acts as an E1 ligase for SUMO1, SUMO2, SUMO3, and probably SUMO4. It mediates ATP-dependent activation of SUMO proteins followed by formation of a thioester bond between a SUMO protein and a conserved active site cysteine residue on UBA2/S
Host	Mouse
Immunogen Region	E. coli-derived human SAE2/UBA2 recombinant protein (Position: E449-K564).
Isotype	Mouse IgG2b
Molecular Weight	90 kDa
Reactivity	Human, Mouse, Rat
Reconstitution	Add 0.2ml of distilled water will yield a concentration of 500ug/ml.
Specificity	No cross reactivity with other proteins.
Synonyms	SUMO-activating enzyme subunit 2; Anthracycline-associated resistance ARX; Ubiquitin-like 1-activating enzyme E1B; Ubiquitin-like modifier-activating enzyme 2; UBA2; SAE2, UBLE1B; HRIHFB2115
Note	Each vial contains 4mg Trehalose, 0.9mg NaCl, 0.2mg Na<sub>2</sub>HPO<sub>4</sub>, 0.05mg NaN<sub>3</sub>.

Uniprot	Q9UBT2
Gene Id	10054
Gene Name	UBA2
Clone No	Clone: 5B13
Subcellular Location	Nucleus; Cytoplasm

Conjugates	Biotin, Cy3, Dylight488, Dylight550, Dylight594, FITC, HRP, APC, PE, iFluor647, carrier-free

Form	Lyophilized
Storage	Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

Applications	WB, IHC
Description	Weste blot, 0.1-0.5ug/ml, Human, Mouse, Rat<br> Immunohistochemistry (Paraffin-embedded Section), 0.5-1ug/ml, Human, By Heat<br>

Reference	1. "Entrez Gene: ubiquitin-like modifier activating enzyme 2". <br /><br />2. Gong L, Li B, Millas S, Yeh ET (April 1999). "Molecular cloning and characterization of human AOS1 and UBA2, components of the sentrin-activating enzyme complex". FEBS Lett. 448 (1): 1859.<br /><br />3. Desterro JM, Rodriguez MS, Kemp GD, Hay RT (April 1999). "Identification of the enzyme required for activation of the small ubiquitin-like protein SUMO-1". J. Biol. Chem. 274 (15): 1061824.<br /><br />

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Combination SKU	Supplier No.	Conjugation	Size	Your price	Quantity
BHA21002390-1	M03816-2	-	100 ug	$370		Add to Cart
BHA21002390-2	M03816-2-10ug	Sample	10 ug	$99		Add to Cart
BHA21002390-3	M03816-2-Biotin	Biotin	100 ug	$570		Add to Cart
BHA21002390-4	M03816-2-Cy3	Cy3	100 ug	$570		Add to Cart
BHA21002390-5	M03816-2-Dylight488	Dylight488	100 ug	$570		Add to Cart
BHA21002390-6	M03816-2-Dylight550	Dylight550	100 ug	$570		Add to Cart
BHA21002390-7	M03816-2-Dylight594	Dylight594	100 ug	$570		Add to Cart
BHA21002390-8	M03816-2-FITC	FITC	100 ug	$570		Add to Cart
BHA21002390-9	M03816-2-HRP	HRP	100 ug	$570		Add to Cart
BHA21002390-10	M03816-2-APC	APC	100 ug	$670		Add to Cart
BHA21002390-11	M03816-2-PE	PE	100 ug	$670		Add to Cart
BHA21002390-12	M03816-2-iFluor647	iFluor647	100 ug	$670		Add to Cart
BHA21002390-13	M03816-2-carrier-free	carrier-free	100 ug	$370		Add to Cart

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