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Home / Primary Antibodies / Monoclonal Antibodies

Anti-PLK1 Antibody Picoband® (monoclonal, 6D11)

SKU : BHA21002270

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Mfr.No.	M00182, M00182-10ug, M00182-Biotin, M00182-Cy3, M00182-Dylight488, M00182-Dylight550, M00182-Dylight594, M00182-FITC, M00182-HRP, M00182-APC, M00182-PE, M00182-iFluor647, M00182-carrier-free
Alternative Names	polo like kinase 1
Background	Serine/threonine-protein kinase PLK1, also known as polo-like kinase 1 (PLK-1) or serine/threonine-protein kinase 13 (STPK13), is an enzyme that in humans is encoded by the PLK1 (polo-like kinase 1) gene. Plk1 is an early trigger for G2/M transition. It supports the functional maturation of the centrosome in late G2/early prophaseand establishment of the bipolar spindle. Also, Plk1 phosphorylates and activates cdc25C, a phosphatase that dephosphorylates and activates the cyclinB/cdc2 complex. Studies have shown that the loss of PLK1 expression can inducepro-apoptotic pathways and inhibit growth. Based on yeast and murine studies of meiosis, human PLK1 may also have a regulatory function in meiosis.
Clonality	Monoclonal
Cross Reactivity	No cross-reactivity with other proteins.
Description	Boster Bio Anti-PLK1 Antibody Picoband® (monoclonal, 6D11) catalog # M00182. Tested in WB applications. This antibody reacts with Human, Monkey. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Weste blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.
Function	Serine/threonine-protein kinase that performs several important functions throughout M phase of the cell cycle, including the regulation of centrosome maturation and spindle assembly, the removal of cohesins from chromosome arms, the inactivation of anaph
Host	Mouse
Immunogen Region	E.coli-derived human PLK1 recombinant protein (Position: K86-N430). Human PLK1 shares 95.4% and 96.2% amino acid (aa) sequence identity with mouse and rat PLK1, respectively.
Isotype	Mouse IgG2b
Molecular Weight	68 kDa
Reactivity	Human, Monkey
Reconstitution	Add 0.2ml of distilled water will yield a concentration of 500ug/ml.
Specificity	No cross reactivity with other proteins.
Synonyms	Serine/threonine-protein kinase PLK1; Polo-like kinase 1; PLK-1; Serine/threonine-protein kinase 13; STPK13; PLK1; PLK
Tissue Specificity	Placenta and colon.
Note	Each vial contains 4mg Trehalose, 0.9mg NaCl, 0.2mg Na<sub>2</sub>HPO<sub>4</sub>, 0.05mg NaN<sub>3</sub>.

Uniprot	P53350
Gene Id	5347
Gene Name	PLK1
Clone No	Clone: 6D11
Subcellular Location	Centrosome. Spindle. Nucleus. Kinetochore. Midbody.

Conjugates	Biotin, Cy3, Dylight488, Dylight550, Dylight594, FITC, HRP, APC, PE, iFluor647, carrier-free

Form	Lyophilized
Purification	Immunogen affinity purified.
Storage	Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

Applications	WB
Description	Weste blot, 0.1-0.5ug/ml<br>

Reference	1. Holtrich U, Wolf G, Bräuninger A, Ka T, Böhme B, Rübsamen-Waigmann H et al. (March 1994). "Induction and down-regulation of PLK, a human serine/threonine kinase expressed in proliferating cells and tumors". Proc. Natl. Acad. Sci. U.S.A. 91(5): 173640.<br /><br />2. Soung NK, Park JE, Yu LR, Lee KH, Lee JM, Bang JK et al. (April 2009). "Plk1-dependent and -independent roles of an ODF2 splice variant, hCenexin1, at the centrosome of somatic cells". Dev. Cell 16(4): 53950.

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Combination SKU	Supplier No.	Conjugation	Size	Your price	Quantity
BHA21002270-1	M00182	-	100 ug	$370		Add to Cart
BHA21002270-2	M00182-10ug	Sample	10 ug	$99		Add to Cart
BHA21002270-3	M00182-Biotin	Biotin	100 ug	$570		Add to Cart
BHA21002270-4	M00182-Cy3	Cy3	100 ug	$570		Add to Cart
BHA21002270-5	M00182-Dylight488	Dylight488	100 ug	$570		Add to Cart
BHA21002270-6	M00182-Dylight550	Dylight550	100 ug	$570		Add to Cart
BHA21002270-7	M00182-Dylight594	Dylight594	100 ug	$570		Add to Cart
BHA21002270-8	M00182-FITC	FITC	100 ug	$570		Add to Cart
BHA21002270-9	M00182-HRP	HRP	100 ug	$570		Add to Cart
BHA21002270-10	M00182-APC	APC	100 ug	$670		Add to Cart
BHA21002270-11	M00182-PE	PE	100 ug	$670		Add to Cart
BHA21002270-12	M00182-iFluor647	iFluor647	100 ug	$670		Add to Cart
BHA21002270-13	M00182-carrier-free	carrier-free	100 ug	$370		Add to Cart

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